血尿酸水平与急性脑梗死的相关性研究

【目的】探讨急性脑梗死与患者血尿酸（BUA）的关系。【方法】急性脑梗死病人50人（A组），根据有无高血压病史分两亚组；同时根据有无糖尿病病史再分为两亚组。以非脑梗死病人50人作为对照组（B组），比较其BUA、总胆固醇（TC）和甘油三酯（TG）水平。【结果】①A组年龄、TC、TG与B组相比，差异无显著性（P〉0．05）；A组BUA（346．56±99．16）μmol／L]明显高于B组（324．71±69．20）μmol／L3（P〈0．05）；②有高血压病史亚组和有糖尿病史亚组BuA，与B组相比差异显著（P〈0．05）；③A组高尿酸血症（HUA）的发生率明显高于B组（P〈0．05）；④BuA水平在〈300μmol／L和300-399μmol／L两水平段时，A组与B组中患者所占比例无明显差异（P〉0．05），而BUA在400-500μmol／L和〉500μmol／L两水平段时，A组患者所占比例明显高于B组，且差异有显著性（P〈0．05）。【结论】HUA可能是急性脑梗死的危险因素之一。

Relationship Between Serum Levels of Uric Acid and Acute Cerebral Infarction

Objective]To explore the relation between serum levels of uric acid and acute cerebral infarction. Methods]Fifty patients with acute cerebral infarction （group A）were divided into two subgroups：hypertention subgroup and non-hypertention subgroup, diabetes subgroup and non-diabetes mellitus subgroup. Noncerebral infarction patients were selected as control group （group B, n = 50）. Serum uric acid, total cholesterol and triglyceride levels were compared among these groups. Results] There was no significant difference in age, total cholesterol and triglyceride between group A and group B （ P 〉0.05）. Serum uric acid （346.56 ± 99.16 μmol/L） in group A was significantly higher than that （324.71±69.20 umol / L） （ P 〈0.05） in group B. Compared with group B, serum uric acid in hypertension subgroup and diabetes subgroup was （347.20±86.57） μmol/L and （379.54± 70.01） μmol/L, respectively, and there was significant difference （ P 〈0. 05）. The incidence of hyperuricemia in group A was significantly higher than that of group B （ P 〈0.05）. While serum uric acid level was below 300 μmol/L or 300-399 mol/L, there was no significant difference between the group A and group B in the proportion of patients （ P 〉0.05）. While serum uric acid level was 400-500μmol/L or above 500μmol/L, the number of the patients in group A was significantly higher than that of group B, and there is significant differenee （ P 〈0.05）. Conclusion]Hyperurieemia is one of important risk factors of acute cerebral infarction.