| 小儿清热止咳口服液澄清工艺比较 |
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| 引用本文： | 王玲,周稚川,高晓黎.小儿清热止咳口服液澄清工艺比较[J].中国实验方剂学杂志,2012,18(10):55-59. |
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| 作者姓名： | 王玲 周稚川 高晓黎 |
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| 作者单位： | 1. 新疆医科大学药学院,乌鲁木齐,830022
2. 新疆医科大学第一附属医院药剂科,乌鲁木齐,830022 |
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| 摘 要： | 目的:优选小儿清热止咳口服液的澄清工艺.方法:比较高速离心法、乙醇沉淀法、ZTC1+1Ⅲ型天然澄清剂法3种澄清工艺对小儿清热止咳口服液中收膏率、麻黄碱和黄芩苷相对含量的影响.结果:乙醇沉淀法为最佳澄清工艺,其工艺条件为药液浓度比1∶1,加95％乙醇调至含醇量60％,冷藏放置6h.结论:优选的澄清工艺稳定,可行.
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| 关 键 词： | 小儿清热止咳口服液 澄清工艺 综合评分法 |
| 收稿时间： | 2011/12/30 0:00:00 |
Comparison of Clarification Technology for Xiao'er Qingre Zhike Oral Solution |
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| WANG Ling,ZHOU Zhi-chuan and GAO Xiao-li.Comparison of Clarification Technology for Xiao''er Qingre Zhike Oral Solution[J].China Journal of Experimental Traditional Medical Formulae,2012,18(10):55-59. |
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| Authors: | WANG Ling ZHOU Zhi-chuan and GAO Xiao-li |
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| Institution: | College of Pharmacy, Xinjiang Medical University, Urmuqi 830022, China;Department of Pharmacy, First Affiliated Hospital of Xinjiang Medical University, Urmuqi 830022, China;College of Pharmacy, Xinjiang Medical University, Urmuqi 830022, China |
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| Abstract: | Objective:To optimize clarification technology of Xiao’er Qingre Zhike oral solution.Method:To compare effect of three clarification technology(high-speed centrifugation method,ethanol precipitation method and ZTC1+1Ⅲadsorption clarify agent method) on yield of extract and relative content of ephedrine and baicalin which were active components in Xiao′er Qingre Zhike oral solution.Result:The best clarification technology was ethanol precipitation method,its technology conditions were:the concentration ratio of sample liquid 1∶1 with adding 95% ethanol to adjust ethanol concentration to 60%,refrigerated 6 h.Conclusion: Optimized clarification technology for Xiao′er Qingre Zhike oral solution was stable and feasible. |
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| Keywords: | Xiao'er Qingre Zhike oral solution clarification technology comprehensive scoring method |
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