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Facilitation of spontaneous and learned spatial behaviours following 6-hydroxydopamine lesions of the lateral septum: a cholinergic hypothesis
Authors:Daniel Galey   Thomas Durkin   Georgeos Sifakis   Eliane Kempf  Robert Jaffard
Affiliation:1. Laboratoire de Psychophysiologie, U.A. CNRS no. 339, Institut de Biologie animale, Universitéde Bordeaux I, Avenue des Facultés, 33405 Talence Cedex France;2. Centre de Neurochimie du CNRS, 5 Rue Blaise Pascal, 67084 Strasbourg Cedex France;1. Health Sciences Research Centre (CICS-UBI), Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal;2. Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University, Maastricht 6200, the Netherlands;3. CNC-Center for Neuroscience and Cell Biology, CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, UC, Biotech Parque Tecnológico de Cantanhede, 3060-197 Cantanhede, Portugal;4. Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal;5. Neurosov, UBImedical, EM506, University of Beira Interior, Covilhã, Portugal;1. Physiology program, Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hatyai Campus, Hatyai, Songkhla 90110, Thailand;2. Biology program, Division of Biological Science, Faculty of Science, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand;3. Biosignal Research Center for Health, Faculty of Science, Prince of Songkla University, Hatyai, Songkhla 90112, Thailand;1. Division of Brain Sciences, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan;2. Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan;3. Division of System Neurophysiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan;4. Department of Physiological Sciences, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan;5. Division of Behavioral Pharmacology, International Center for Brain Science, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan;6. Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan;7. Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan;8. Division of Regenerative Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan;9. RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;10. Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10 Higashiogu, Arakawa-ku, Tokyo 116-8551, Japan;11. Section of Electron Microscopy, Supportive Center for Brain Research, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan;12. Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan;13. Faculty of Food and Agricultural Sciences, Fukushima University, Kanayagawa, Fukushima 960-1248, Japan;14. Department of Psychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan;15. Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan;16. Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329-0498, Japan;17. Division of Ultrastructural Research, National Institute for Physiological Sciences, Okazaki 444-8787, Japan;18. Department of Anatomy and Embryology, University of Hokkaido, Sapporo, Hokkaido 060-8638, Japan;1. Department of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, 157 Health Road, Nangang District, Harbin, Heilongjiang 150081, PR China;2. The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, 157 Health Road, Nangang District, Harbin, Heilongjiang 150081, PR China;1. Translational Neurology Group, Department of Clinical Sciences, Wallenberg Neuroscience Center, Lund University, Lund, Sweden;2. Department of Neurology, Scania University Hospital, Lund, Sweden;1. Brain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3US, UK;2. Royal Hallamshire Hospital, Department of Neurosurgery, Sheffield S10 2JF, UK
Abstract:
Mice received injections of 6-hydroxydopamine (6-OHDA) in the lateral septum; they were tested for spontaneous alternation, acquisition and reversal of a spatial discrimination in a T-maze. In each of these tasks, performance of 6-OHDA lesioned mice was improved relative to controls. Neurochemical analysis revealed that 6-OHDA lesioned mice exhibited a significant increase in the rate of sodium-dependent high affinity choline uptake in the hippocampus. These results are discussed in relation to current theories concerning the role of the septo-hippocampal complex and cholinergic system in the control of behaviour.
Keywords:pontaneous alternation   spatial discrimination   6-hydroxydopamine (6-OHDA)   lateral septum   high affinity choline uptake   hippocampus   mouse
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