| 二氯醋酸钠激活C6细胞线粒体代谢途径的体外作用(英文) |
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| 引用本文： | 赵欣,王欣,余克富,段瑀,李捷思,赵炳祥,张烜,张强. 二氯醋酸钠激活C6细胞线粒体代谢途径的体外作用(英文)[J]. 中国药学, 2011, 20(5): 460. DOI: 10.5246/jcps.2011.05.058 |
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| 作者姓名： | 赵欣 王欣 余克富 段瑀 李捷思 赵炳祥 张烜 张强 |
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| 作者单位： | 北京大学医学部药学院药剂学系;北京大学医学部天然药物及仿生药物国家重点实验室; |
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| 基金项目： | National Natural Science Foundation of China (Grant No.30873170); the National Basic Research Program of China(973 Program 2007CB935800 and 2009CB930300) |
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| 摘 要： | 肿瘤细胞线粒体代谢途径己成为抗肿瘤的关注点。二氯醋酸钠(DCA)是作用于线粒体的小分子物质,显示出一定的抗肿瘤作用。因此,本文考察DCA对C6脑胶质瘤细胞线粒体代谢途径的影响。实验结果显示,DCA可显著增加C6细胞丙酮酸脱氢酶(FDH)的活性、诱导C6细胞氧活性物质(ROS)的生成,显著降低C6细胞线粒体膜电位(MMP)。上述结果表明,DCA可通过激活C6细胞线粒体代谢途径产生抗肿瘤作用。线粒体代谢途径将成为抗肿瘤治疗的新靶点。
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| 关 键 词： | 线粒体代谢 二氯醋酸钠 C6脑胶质瘤细胞 丙酮酸脱氢酶 氧活性物质 线粒体膜电位 |
Effects of dichloroacetate on the activation of the mitochondrial pathway in C6 cells in vitro |
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| Xin Zhao,Xin Wang,Ke-Fu Yu,Yu Duan,Jie-Si Li,Bing-Xiang Zhao,Xuan Zhang,Qiang Zhang. Effects of dichloroacetate on the activation of the mitochondrial pathway in C6 cells in vitro[J]. Journal of Chinese Pharmaceutical Sciences, 2011, 20(5): 460. DOI: 10.5246/jcps.2011.05.058 |
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| Authors: | Xin Zhao Xin Wang Ke-Fu Yu Yu Duan Jie-Si Li Bing-Xiang Zhao Xuan Zhang Qiang Zhang |
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| Affiliation: | Xin Zhao~1,Xin Wang~1,Ke-Fu Yu~1,Yu Duan~1,Jie-Si Li~1,Bing-Xiang Zhao~1,Xuan Zhang~(1*),Qiang Zhang~(1,2) 1.Department of Pharmaceutics,School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing 100191,China 2.State Key Laboratory of Natural and Biomimetic Drugs,China |
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| Abstract: | Mitochondria are increasingly recognized as important targets for tumor treatment because of their central roles in apoptotic pathways and cellular metabolism.Dichloroacetate(DCA),a low molecular weight mitochondria-targeting agent, exhibits potential therapeutic effects for tumors.Based on the effects of DCA on tumor cellular metabolism,we carried out this study to investigate the anti-tumor activity of DCA in C6 glioma cells in vitro.The results showed that DCA was able to increase the activity of pyruvat... |
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| Keywords: | Mitochondria metabolism Dichloroacetate C6 glioma Pyruvate dehydrogenase Reactive oxygen species Mitochondrial membrane potential |
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