Blockade der chemischen Thermogenese und Auslösung von Muskelzittern durch Adrenolytica und Ganglienblockade beim neugeborenen Meerschweinchen

Summary As has been previously shown young newborn guinea pigs do not shiver on cold exposure although oxygen consumption is considerably increased, i.e. chemical thermogenesis (non-shivering thermogenesis) is the prevailing mechanism of heat production. In the course of the first weeks of life non-shivering thermogenesis is gradually replaced by shivering thermogenesis. In the present study it has been shown that the cold-induced oxygen uptake can be reduced in guinea pigs, 0 to 2 days of age, from 69 to 38 ml/kg min by Alderlin, an adrenergic -receptor blocking agent. This effect was accompanied by an onset of shivering demonstrating that the shivering mechanism is already developed at the time of birth but is not set in function under normal conditions. Similar results have been obtained using Hexamethonium-Bromide and Dichloroisoproterenol. The elicitation of shivering following the administration of the drugs prevents the oxygen uptake from being reduced to the basal level (ca. 20 ml/kg min). When shivering was already present as in older animals (2 to 3 weeks of age) it remained uninfluenced by Alderlin (as veryfied by electromyography); the agent was thus considered suitable to block selectively chemical thermogenesis. On this basis, it was estimated from further data that the contribution of nonshivering thermogenesis to the total heat production is reduced from 91 to 26% within the first three weeks of life. Moreover, it could be shown that the shivering mechanism is less effective than chemical thermogenesis.

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Mit 4 Textabbildungen

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Mit Unterstützung der Deutschen Forschungsgemeinschaft.