2000例门诊和住院患者中HIV与HBV、HCV混合感染的血清学分析

目的分析医院对艾滋病病毒(HIV)抗体筛选结果,了解HIV感染与HBV、HCV肝炎病毒混合感染的关系.方法1998年6月～1999年6月采用ELISA法、MEIA(微粒子酶免法)对HIV、HBV、HCV检测.结果(1)抗HIV感染率为1.4%,其中男性占1.8%,女性占0.9%.民族分布维吾尔族占3.09%,汉族占0.27%,回族占0.77%;维吾尔族与汉族感染率有极显著性差异(χ2=25.34;P＜0.01).(2)在HIV阳性血清中抗HIV单一感染率14.29%;HIV、HCV双重感染率60.71%,HIV、HBV、HCV三重感染率25%;HIV、HCV与HIV、HBV、HCV混合感染率有极显著性差异(χ2=23.9;P＜0.01).结论在本组血清中HIV感染率高,HCV阳性在HIV/AIDS病人血清中混合感染率高,这与青年人静注毒品有关.HIV与HCV有共同传播途径--血液传播.

Serological analysis of 2 000 cases of ambulatory and hospitalized patients with mixed HIV and HBV and HCV infections

Objective: To analyse screening results on ADIS virus antibody in hospitals and to investigate HIV infection in relation with HBV and HCV infections. Methods: We have collected 2 000 samples of blood serum from ambulatory and hospitalized patients from June 1998 to June 1999, and detected HIV(1 2 type), HBV- , anti - HCV by ELISA and Mi-crosome Enzyme Immunoassay tests. Results: (1) The total anti-HIV infection rate was 1.4% (28/2 000), of which the infection rate in male was 1.8% (2/1 098), in female -0.9% (8/902); the infection rate in Uygur nationality was 3. 09% (24/776), that in Han nationality was 0.27% (3/1 094), in Hui nationality -0.77%(1/130) ; the difference between the Uygur and the Han nationalities was significant (x2=25. 34, P < 0. 01). (2) The anti - HIV single infection rate was 14.29 % in HIV positve serum samples, the anti - HIV anti - HCV double infection rates were 60. 71 % (24/28) ; the anti - HIV HBV anti-HCV triple infection rates were 25% (7/28) ; the anti - HIV anti - HCV and anti - HIV HBV anti - HCV mixed infection rates were significantly different (x2 = 23.9, P<0.01). Conclusion: In blood samples the HIV infection rate was high, and the anti - HCV positive mixed infection rate was also high in blood samples with HIV/ AIDS. This was associated with drug injection among the youth, indicating that hematogenic infection was the common route of HIV and HCV transmission.