| CerbB-2、nm23、ER及PR在乳腺癌中的表达及临床意义 |
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| 引用本文： | 柴小兰,韩渊. CerbB-2、nm23、ER及PR在乳腺癌中的表达及临床意义[J]. 海南医学, 2009, 20(7): 7-10 |
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| 作者姓名： | 柴小兰 韩渊 |
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| 作者单位： | 新疆医科大学第五附属医院病理科,新疆,乌鲁木齐,830011;新疆医科大学第五附属医院病理科,新疆,乌鲁木齐,830011 |
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| 摘 要： | 目的研究乳腺癌癌基因C—erbB-2、抑癌基因nm23和雌激素（ER）、孕激素受体（PR）的表达及意义。方法应用免疫组化SP法检测54例浸润性乳腺癌C—erbB-2、nm23及雌、孕激素受体的表达。结果1）C—erbB-2表达与肿瘤病理组织学分级、淋巴结转移呈正相关,与肿瘤类型、临床分期、肿瘤大小、患者年龄无统计学意义。2）mn23的表达与肿瘤临床分期、淋巴结转移呈负相关,与肿瘤类型、组织学分级、肿瘤大小、患者年龄无统计学意义。3）C—erbB-2与ER表达呈负相关,与PR表达无统计学意义;nm23表达与ER、PR表达呈无显著性正相关,与C—erbB-2表达呈负相关。结论C-erbB-2、nm23、ER及PR的联合检测能够较好地反映乳腺癌分子生物学特征。
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| 关 键 词： | 乳腺癌 C-erbB-2 nm23 ER PR 基因 |
Expression of C-erbB-2, nm23, ER and PR in breast carcinoma and its clinical significance |
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| CAI Xiao-lan,HAN Yuan. Expression of C-erbB-2, nm23, ER and PR in breast carcinoma and its clinical significance[J]. Hainan Medical Journal, 2009, 20(7): 7-10 |
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| Authors: | CAI Xiao-lan HAN Yuan |
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| Affiliation: | CAI Xiao-lan,HAN Yuan.Department of Pathology,the Fifth Hospital Affiliated to Xinjiang Medical University,Urumqi,830011,Xinjiang,P.R.CHINA |
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| Abstract: | Objective To investigate the expression and significance of C-erbB-2,nm23 protein,estrogen receptor(ER) and progestogen receptor(PR) in breast carcinoma.Methods 54 cases of surgical specimens from infiltrating breast cancer were investigated by SP immunohistochemical staining for C-erbB-2 oncogene,nm23 gene protein,ER and PR.Results 1) The positive rate of C-erbB-2 was 48.1%,which was positively correlated with histolgical grade and lymph node metastasis(P<0.05),but that did not relate to histological types... |
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| Keywords: | C-erbB-2 nm23 ER PR |
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