Effects of alpha-lipoic Acid on body weight in obese subjects |
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| Authors: | Koh Eun Hee Lee Woo Je Lee Sang Ah Kim Eun Hee Cho Eun Hee Jeong Eunheui Kim Dong Woo Kim Min-Seon Park Joong-Yeol Park Keun-Gyu Lee Hyo-Jung Lee In-Kyu Lim Soo Jang Hak Chul Lee Ki Hoon Lee Ki-Up |
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| Affiliation: | aDepartment of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea;bDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea;cDepartment of Internal Medicine, and Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Republic of Korea;dDepartment of Internal Medicine, Seoul National University College of Medicine, and Seoul National University Bundang Hospital, Seongnam, Republic of Korea;eSchool of Business, Jeonju University, Jeonju, Republic of Korea |
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| Abstract: | PurposeAlpha-lipoic acid is an essential cofactor for mitochondrial respiratory enzymes that improves mitochondrial function. We previously reported that alpha-lipoic acid markedly reduced body weight gain in rodents. The purpose of this study was to determine whether alpha-lipoic acid reduces body weight in obese human subjects.MethodsIn this randomized, double-blind, placebo-controlled, 20-week trial, 360 obese individuals (body mass index [BMI] ≥30 kg/m2 or BMI 27-30 kg/m2 plus hypertension, diabetes mellitus, or hypercholesterolemia) were randomized to alpha-lipoic acid 1200 or 1800 mg/d or placebo. The primary end point was body weight change from baseline to end point.ResultsThe 1800 mg alpha-lipoic acid group lost significantly more weight than the placebo group (2.1%; 95% confidence interval, 1.4-2.8; P < .05). Urticaria and itching sensation were the most common adverse events in the alpha-lipoic acid groups, but these were generally mild and transient.ConclusionAlpha-lipoic acid 1800 mg/d led to a modest weight loss in obese subjects. Alpha-lipoic acid may be considered as adjunctive therapy for obesity. |
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| Keywords: | Alpha-lipoic acid Anti-obesity agent Side effect |
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