Leukaemic non-Hodgkin's lymphomas with hyperdiploid cells and t(ll;14)(ql3;q32): a subtype of mantle cell lymphoma? |
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| Authors: | MARIE-THERESE DANIEL ISABELLE TIGAUD MARIE-ANGE FLEXOR MARIA-ELENA NOGUEIRA ROLAND BERGER PHILIPPE JONVEAUX |
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| Affiliation: | 1Laboratoire Central d'Hematologie, Hopital Saint-Louis, Paris;Unite INSERM U 301 and DSI No. 15954 I CNRS, 1GM, Paris;Laboratoire Central d'Hematologie, Hopital E. Herriot, Lyon, France |
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| Abstract: | ![]()
The present study describes five patients with leukaemic non-Hodgkin's lymphoma (NHL) detected on the basis of particular morphology and cytogenetic findings. With respect to histological, immunological and cytogenetic features these NHL are closely related to mantle cell Iymphoma/intermediate differentiated lymphocytic lymphoma. However, the presence of unusual large cells associated with the t(ll;14)(ql3;q32) translocation and numerical chromosome changes, in the near triploid or near tetraploid range, could delineate a particular subtype of mantle cell lymphoma. |
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| Keywords: | leukaemic mantle cell lymphoma hyperdiploid cells t(ll 14)(q!3 q32) BCL1/CCND11 |
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