HLA-DRB1 and anti-cyclic citrullinated peptide antibody production in rheumatoid arthritis |
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Authors: | Senkpiehl Ilka Marget Matthias Wedler Martina Jenisch Stefan Georgi Joachim Kabelitz Dietrich Steinmann Jorg |
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Affiliation: | Department of Immunology, UKS-H Campus Kiel, Germany. |
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Abstract: | Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expression of anti-CCP correlates with the carriage of certain genes on the HLA-DRB1 locus. Our data reveal a highly significant association between anti-CCP and HLA-DR4, and a weaker but still significant association with HLA-DR1. HLA-DRB1*0401 is not a prerequisite for anti-CCP production, but if HLA-DRB1*0401 was present, 90% of our RA patients were anti-CCP positive. |
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