| 丙泊酚治疗难治性癫痫持续状态的临床研究进展 |
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| 引用本文： | 王恒林,王卓强,米卫东,王永安. 丙泊酚治疗难治性癫痫持续状态的临床研究进展[J]. 国际药学研究杂志, 2008, 35(1): 23-26 |
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| 作者姓名： | 王恒林 王卓强 米卫东 王永安 |
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| 作者单位： | 解放军总医院第二附属医院麻醉科,北京,100091;解放军总医院麻醉科,北京,100853;解放军总医院第二附属医院麻醉科,北京,100091;解放军总医院麻醉科,北京,100853;军事医学科学院毒物药物研究所,北京,100850 |
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| 摘 要： | 难治性癫痫持续状态是一种严重的内科急症，具有很高的死亡率，临床治疗非常棘手。近年来，越来越多的临床研究和病例报告显示，丙泊酚（又名异丙酚）对难治性癫痫持续状态有较好的疗效，但治疗过程中也有发生严重并发症的危险。本文综述了近年来丙泊酚治疗难治性癫痫持续状态的临床研究进展及其可能的作用机制。
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| 关 键 词： | 丙泊酚 癫痫持续状态 药物疗法 |
| 文章编号： | 1674-0440(2008)01-0023-04 |
| 收稿时间： | 2007-04-23 |
| 修稿时间： | 2007-04-23 |
Progress of propofol in the clinical treatment of refractory status epilepticus |
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| WANG Heng-lin,WANG Zhuo-qiang,MI Wei-dong,WANG Yong-an. Progress of propofol in the clinical treatment of refractory status epilepticus[J]. Foreign Medical Sciences(Section of Pharmarcy), 2008, 35(1): 23-26 |
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| Authors: | WANG Heng-lin WANG Zhuo-qiang MI Wei-dong WANG Yong-an |
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| Affiliation: | （1.Department of Anesthesiology, the Second Affiliated Hospital of Chinese PLA General Hospital, Beijing 100091; 2.Department of Anesthesiology, Chinese PLA General Hospital, Beijing 100853; 3.Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China） |
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| Abstract: | Refractory status epilepticus, a severe emergency with high mortality, is hard to be dealed with in clinics. Recently, more and more clinical researches and case reports showed that propofol could produce significantly anticonvulsant effect on refractory status epilepticus even though it has possibly severe complication in the course of treatment. This paper reviews the current progress of propofol in the clinical treatment of refractory status epilepticus and its possible mechanisms. |
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| Keywords: | propofol status epilepticus drug therapy |
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