盐酸羟考酮缓释片治疗中重度癌痛的临床观察

目的：观察盐酸羟考酮缓释片通过剂量滴定治疗中重度癌性疼痛的疗效及不良反应。方法78例中重度癌性疼痛患者，用剂量滴定的方法使用盐酸羟考酮缓释片进行止痛治疗。根据疼痛缓解程度调整剂量。连续用药至少2周，同时进行止痛效果、生活质量及不良反应的观察。结果经剂量滴定后78例中重度癌性疼痛患者口服盐酸羟考酮缓释片剂量范围10～160mg/次，q12h。患者中疼痛完全缓解24例（30.77%），部分缓解52例（66.67%），总的疼痛缓解率（CR＋PR）为97.44%；中度疼痛缓解率为100.00%，重度疼痛缓解率为90.48%；患者生活质量明显提高，不良反应较少。主要不良反应为便秘，其次为恶心、呕吐、头晕等。结论盐酸羟考酮缓释片通过剂量滴定的方法，可有效控制中重度癌性疼痛，不良反应较少，能显著地改善癌痛患者的生活质量。

Clinical observatin of oxycodone in the treatment of 78 cases with moderate and severe cancer pain

Objective To observe the analgesic effect and adverse effects of Oxycontin（Oxycodone Hydrochloride Controlled-release Tablets） with dose titration therapy on moderate and severe chronic cancer pain. Methods A total of 78 patients with moderate and severe chronic cancer pain were selected to be treated with Oxycontin. Oxycontin with dose titration therapy was administered at initial dose of 10mg every 12 hours, and was titrated upwards according to the extend of pain relief.All patients were treated for at least 2 weeks,simultaneously the analgesic effect, adverse effects and quality of life was investigated. Results Among the 78 patients suffering moderate and severe chronic cancer pain,The doses ranged between 10mg/to 160mg/12h. 24（30.77%） achieved complete remission, 52（66.67%） achieved partial remission, Total pain relief was 97.44%, and it was 100.00% in patients with moderate chronic cancer pain, 90.48% in patients with severe chronic cancer pain. The quality of life was significantly improved after the treatment with mild adverse effect.The main adverse effects were constipation,nausea and vomiting, and dizziness. Conclusion With dose titration therapy, Oxycodone are effective in controlling moderate and severe chronic cancer pain, and mproved the quality of life of patients significantly with mild adverse effect.