一氧化氮与原发性高血压及左室肥厚的关系

目的 探讨一氧化氮（NO）在原发性高血压（EH）患者中的变化，以及与左室肥厚（LVH）的关系。方法 分别选取EH有LVH患者、EH无LVH患者及正常人各30例，检测NO水平及左室重量（LVM），进行组间比较及相关分析。结果 1．EH有LVH组NO水平明显低TEH无LVH组、正常对照组，EH无LVH组NO水平明显低于正常对照组；而室间隔舒张末期厚度（IVS）、左室后壁舒张末期厚度（LVPw）、LVM水平相反俨〈0．01）。2．血压与NO呈负相关、与LVM呈正相关，NO与LVM呈负相关（r〉0或，〈0，P〈0．01或〈0．05）。结论 NO参与了EH及LVH形成的病理生理过程。

Correlation between nitric oxide and essential hypertension and left ventricular hypertrophy

Objective To investigate the correlation between nitric oxide （ NO ） and essential hypertension （ EH ） and left ventricular hypertrophy （LVH）. Methods NO and left ventricular mass index （LVMI） were measured in 30 patients with EH （EH group）, 30 patients with EH and LVH （EH＋LVH group）, and 30 normal controls （NC group）. The results were treated by analysis of variance and correlation. Results 1. NO level in EH ＋LVH group was lower than＇that in NC and EH groups, and it was lower in EH group than that in NC group, while LVMI level was higher in EH＋LVH group （P〈0.01）; 2. There was a negative correlation between blood pressure and NO, while there was a positive correlation between blood pressure and LVMI, and a negative correlation between NO and LVMI （P 〈 0.01 or 〈 0.05）. Conclusions NO was involved in the pathophysiological process of EH or EH＋LVH.