| 蜕皮甾酮对实验性糖尿病大鼠肾组织氧化应激的影响 |
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| 引用本文： | 邹德平,许志忠,曹灵,陈秋. 蜕皮甾酮对实验性糖尿病大鼠肾组织氧化应激的影响[J]. 中国中西医结合肾病杂志, 2010, 11(1): 28-30,I0003 |
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| 作者姓名： | 邹德平 许志忠 曹灵 陈秋 |
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| 作者单位： | 1. 四川省眉山市人民医院肾内科,眉山,620010
2. 泸州医学院附属医院,泸州,646000 |
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| 基金项目： | 四川省重大攻关项目(No.2006Z-046) |
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| 摘 要： | 目的：观察蜕皮甾酮对早期糖尿病肾病大鼠肾脏氧化应激的影响。方法：用STZ复制糖尿病的大鼠模型,分为阳性对照组（D组）、洛汀新治疗组（L组）、小剂量蜕皮甾酮治疗组（S组）、大剂量蜕皮甾酮治疗组（M组）以及阴性对照组（N组）共5组,灌胃治疗6周后杀检。ELISA法检测肾组织匀浆NOS、AngⅡ、SOD、MDA的含量。结果：与D组相比,N组、S组以及M组NOS含量降低且差异有统计学意义;N组和L组AngⅡ含量降低差异有统计学意义;N组、S组以及M组SOD的含量增加差异有统计学意义;N组、S组以及M组MDA的含量降低差异有统计学意义。结论：蜕皮甾酮能防治1型糖尿病大鼠体重减轻和降低ACR。蜕皮甾酮可能通过减少肾组织MDA、NOS含量以及增加肾组织SOD水平发挥抗氧化效应,具有防治DN的作用。
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| 关 键 词： | 蜕皮甾酮 糖尿病肾病 氧化应激 |
Effects of Ecdysterone on Oxidative Stress on Nephropathy in STZ-induced Diabetic Rats |
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| ZOU Deping,XU Zhizhong,CAO Ling,et al. Effects of Ecdysterone on Oxidative Stress on Nephropathy in STZ-induced Diabetic Rats[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2010, 11(1): 28-30,I0003 |
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| Authors: | ZOU Deping XU Zhizhong CAO Ling et al |
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| Abstract: | Objective:To investigate the influence of ecdysterone on oxidative stress on nephropathy in STZ-induced diabetic rats.Methods:Rat model of diabetic nephropathy was induced by STZ.And the model rats were divided into 5 groups: the positive control group(the D group),the group treated with Lortensin(the L group),the group treated with low dose of ecdysterone(the S group),the group treated with high dose of ecdysterone(the M group),and the group of negative control(the N group).Rats were treated with ecdystero... |
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| Keywords: | Ecdysterone Diabetic nephropathy Oxidative stress |
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