微淋巴管密度与乳腺浸润性导管癌进展的关系

目的探讨微淋巴管密度与乳腺浸润性导管癌进展的关系。方法对咸宁学院附属第一医院病理科2007年5月至2009年9月存档的73例乳腺IDC组织采用鼠抗人D2-40、VEGFR-3单克隆标记,免疫组化S-P二步法在光镜下观察LMVD。结果 73例D2-40、VEGFR-3标记乳腺IDC组织LMVD明显高于乳腺纤维瘤组织LMVD,两者差异具有统计学意义（P〈0.01）;不同分期的乳腺IDC组织LMVD差异显著,具有统计学意义（P〈0.05）。结论乳腺IDC中存在微淋巴管的生成,与其发展关系密切,LMVD可作为预测乳腺IDC转移和预后的重要依据。

Relationship between Lymphatic Microvessel Density and Progression of Breast Invasive Ductual Carcinoma

Objective To investigate the relationship between Lymphatic Microvessel Density and progression of Breast Invasive Ductual Carcinoma.Methods The data of 73 cases with breast invasive ductual carcinoma were collected.Monocolonal antibody D2-40 and VEGFR-3 were used to mark endotheliocyte of lymphatic vessels by two-step immunohistochemical staining.Lymphatic microvessels density was observed and counted under microscope.Results LMVD marked by D2-4 and VEGFR-3 in breast invasive ductual carcinoma was significantly higher than that in breast fibroadenoma（P0.01）.LMVD in different pTNM stage was significantly different（P0.05）.Conclusion Lymphatic microvessels can be found in breast invasive ductual carcinoma,which is closely related with the development of breast invasive ductual carcinoma.Conclusion LMVD might be served as a important basis to evaluate the prognosis of patients with breast invasive ductual carcinoma.