|
|||||
|
|
| 系统性红斑狼疮患者外周血CD14+单核细胞表面TLR2、TLR4表达的变化 | |
| 引用本文： | 武加标,李志军,李柏青,陈琳洁,唐洁,任敏. 系统性红斑狼疮患者外周血CD14+单核细胞表面TLR2、TLR4表达的变化[J]. 蚌埠医学院学报, 2011, 36(1): 4-6,10 |
| 作者姓名： | 武加标 李志军 李柏青 陈琳洁 唐洁 任敏 |
| 作者单位： | 1. 江苏大学附属武进医院血液风湿科, 江苏常州 213100;2. 蚌埠医学院第一附属医院风湿免疫科, 安徽蚌埠 233004;3. 感染与免疫安徽省重点实验室, 安徽蚌埠 233030 |
| 摘 要： | 目的:探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)患者外周血单核细胞表面Toll样受体2(toll-likereceptor-2,TLR2)和Toll样受体4(toll-like receptor-4,TLR4)表达的变化。方法:流式细胞术分别检测75例SLE患者(SLE组)和44名正常人(对照组)外周血单核细胞表面TLR2和TLR4的阳性率和平均荧光强度(meam fluorescence intensity,MFI)。统计分析TLR2和TLR4阳性率和MFI与相关临床与实验室指标的相关性。结果:TLR2在SLE组外周血CD14+单核细胞表面的阳性率和MFI均低于对照组;而TLR4在SLE组外周血CD14+单核细胞表面的阳性率高于对照组,但MFI表达低于对照组(P<0.01)。TLR2阳性率与SLE活动指数呈负相关(P<0.01)。结论:TLR2和TLR4在SLE患者外周血CD14+单核细胞表面表达有显著变化,提示可能与SLE的发生及病情存在一定的关联。 |
| 关 键 词： | 红斑狼疮 系统性 Toll样受体 单核细胞 流式细胞术 |
| 收稿时间： | 2010-01-15 |
Expression of toll-like receptor-2 and toll-like receptor-4 in peripheral blood monocytes of patients with systemic lupus erythematosus |
|
| WU Jia-biao,LI Zhi-jun,LI Bai-qing,CHEN Lin-jie,TANG Jie,REN Min. Expression of toll-like receptor-2 and toll-like receptor-4 in peripheral blood monocytes of patients with systemic lupus erythematosus[J]. Journal of Bengbu Medical College, 2011, 36(1): 4-6,10 | |
| Authors: | WU Jia-biao LI Zhi-jun LI Bai-qing CHEN Lin-jie TANG Jie REN Min |
| Affiliation: | 1. Department of Rheumatology, Wujin Hospital Affiliated to Jiangsu University, Changzhou Jiangsu 213100;2. Department of Rheumatology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004;3. Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu Anhui 233030, China |
| Abstract: | Objective:To investigate the changes of toll like receptors-2(TLR2)and toll like receptors-4(TLR4)on the surface of CD14+ monocytes in the peripheral blood of patients with systemic lupus erythematosus(SLE).Methods:The expression rate and intensity of TLR2 and TLR4 on the CD14+ monocytes in the peripheral blood of 75 patients with SLE and 44 normal controls were determined by flow cytometry.The TLR2 and TLR4 expression rates,the mean fluorescence intensity(MFI) and the related clinical and laboratory indica... |
| Keywords: | lupus erythematosu systemic toll-like receptor monocytes flow cytometry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《蚌埠医学院学报》浏览原始摘要信息 | |
| 点击此处可从《蚌埠医学院学报》下载全文 | |