| 脑胶质瘤中血脑屏障的超微结构特点 |
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| 引用本文： | 王玮,林志雄.脑胶质瘤中血脑屏障的超微结构特点[J].解剖学杂志,1996,19(1):55-58. |
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| 作者姓名： | 王玮 林志雄 |
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| 作者单位： | 福建医学院人体解剖学教研室，福建医学院人体解剖学教研室，福建医学院人体解剖学教研室，附属第一医院神经外科，附属第一医院神经外科 福州350004，福州350004 |
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| 基金项目： | 福建省自然科学基金资助项目 |
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| 摘 要： | ８例胶质瘤病例，标本分别取自同一病例的瘤体，瘤周水肿区和邻近脑组织。瘤体和瘤周水肿区血脑屏障超微结构变化无明显差异，内皮肿胀，毛细血管腔狭小，腔面有稀疏的绒毛样突起，内皮为无孔型，胞质内胞饮泡较多，内皮紧密连接增长，细胞连接间隙增宽，基膜完整，基膜完整，胶质膜缺损。
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| 关 键 词： | 胶质瘤 血脑屏障 脑肿瘤 |
CHARACTERISTIC FEATURES OF THE ULTRASTRUCTURE OF CEREBRAL GLIOMAS |
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| Wang Wei, Lin Zhixiong,Dai Fuzhen, Chen Jinfeng,Huang Haihui.CHARACTERISTIC FEATURES OF THE ULTRASTRUCTURE OF CEREBRAL GLIOMAS[J].Chinese Journal of Anatomy,1996,19(1):55-58. |
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| Authors: | Wang Wei Lin Zhixiong Dai Fuzhen Chen Jinfeng Huang Haihui |
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| Institution: | Wang Wei,* Lin Zhixiong,Dai Fuzhen,* Chen Jinfeng,Huang Haihui |
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| Abstract: | Specimens of 8 gliomas were taken from the tumor, peritumoral oedematous region and adjacent cerebral tissue of each patient. Blood-brain barrier in tumors and peritumoral oedematous regions had the same variations in ultrastructure. Endothelia were swellon, but not fenestrated. Endothelia had an abundance of pinocytotic vesicles, longer tight junctions and enlarged junctional clefts, and intact basement membrane. The lumina of capillaries were strictured with sparse villus-like prominences. The glial limitans outside the basement membrane of capillaries were damaged. These variations were not observed in adjacent cerebral tissues. In addtion, freeze-fracture studies showed that orthogonal arrays of panicles were clustered on the endothelium-facting membranes of astrocytes that might be potassium channels. |
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| Keywords: | cerebrum glial cell glioma blood-brain barrier |
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