Shortened megakaryocyte-platelet regeneration time in patients with ischemic cerebrovascular disease |
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| Authors: | M. Hamberg, J. Svensson, M. Blomb ck,K.L. Mettinger |
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| Affiliation: | 1. Department of Chemistry, Karolinska Institute, Stockholm, Sweden;2. Department of Clinical Chemistry, Danderyd Hospital, Stockholm, Sweden;3. Departments of Blood Coagulation Disorders, Stockholm, Sweden;4. Neurology, Karolinska Hospital, Stockholm, Sweden |
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| Abstract: | ![]()
A method for determination of megakaryocyte-platelet regeneration time (MPT) based on measurement of the rate of reappearance of platelet cyclooxygenase activity following oral aspirin was recently developed in our laboratories. The method was applied to apparently healthy subjects as well as to patients with ischemic cerebrovascular disease. The mean regeneration half time in the former group was 5.2 ± 0.15 (S.E.M.) days (n=11) and in the latter group, 4.2 ± 0.21 (S.E.M.) days (n=11). The difference between the two groups was statistically significant (p < 0.01). |
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| Keywords: | Ischemic cerebrovascular disease platelet kinetics thromboxane B2 |
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