| 雷米普利对原发性高血压病患者微量蛋白尿及其血浆VWF和血清HsCRP的影响 |
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| 引用本文： | 杨海涛,黄鹏,林燕.雷米普利对原发性高血压病患者微量蛋白尿及其血浆VWF和血清HsCRP的影响[J].吉林医学,2012,33(21):4492-4494. |
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| 作者姓名： | 杨海涛 黄鹏 林燕 |
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| 作者单位： | 杨海涛 (深圳市北大医院,广东深圳,518035) ； 黄鹏 (深圳市北大医院,广东深圳,518035) ； 林燕 (深圳市北大医院,广东深圳,518035) ； |
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| 摘 要： | 目的:探讨雷米普利治疗原发性高血压病患者对患者的血压,微量蛋白尿的疗效以及对血浆血管性假性血友病因子(VWF)和血清高敏C-反应蛋白(HsCRP)水平的影响。方法:选取未经药物治疗的原发性高血压1级患者50例为治疗组,同时选取健康志愿者20例为正常对照组。采用雷米普利2.5～5.0 mg,1次/d,治疗前及治疗后测血压,血浆VWF和血清HsCRP水平以及24 h尿蛋白量。结果:经雷米普利治疗后血压、尿蛋白量及血清VWF和HsCRP水平显著下降(P<0.01)。结论:雷米普利不仅可降低原发性高血压患者血压,还能显著降低尿微量白蛋及血浆VWF和血清HsCRP的水平。
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| 关 键 词： | 雷米普利 原发性高血压 尿微量白蛋白排泄量 血浆血管性假性血友病因子(VWF) 血清高敏C-反应蛋白(HsCRP) |
Impact of Ramipril on Microalbuminuria,Serum VWF and Plasma HsCRP in Patients with Essential Hypertension |
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| YANG Hai-tao,HUANG Peng,LIN Yan.Impact of Ramipril on Microalbuminuria,Serum VWF and Plasma HsCRP in Patients with Essential Hypertension[J].Jilin Medical Journal,2012,33(21):4492-4494. |
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| Authors: | YANG Hai-tao HUANG Peng LIN Yan |
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| Institution: | (Peking University First Hospital of Shenzhen City,Guangdong Shenzhen 518035) |
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| Abstract: | Objective To evaluate impact of ramipril on microalbuminuria,serum VWF and plasma HsCRP in patients with essential hypertension.Methods To choose 50 primary essential-hypertension-patients with no treatment as treatment group and 20 healthy volunteers as control group.To observe blood pressure,plasma VWF and serum HsCRP level and 24 hours of urinary protein before and after the treatment with ramipril 2.5～5.0 mg once per day.Results It suggests that blood pressure,urine protein quantity,serum VWF and HsCRP’s level be decreased significantly(P<0.01) after treatment of ramipril.Conclusion The ramipril can decrease,obviously,the essential-hypertension-patients’ blood pressure as well as microalbuminuria,serum VWF and plasma HsCRP level. |
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| Keywords: | Ramipril Essential hypertension Urinary albumin excretion plasma VWF HsCRP |
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