《中华本草》药性数据中的四气规律

目的:以四气为核心,分析中药药性数据中气与味、归经、毒性之间的相关关系,为中医临床用药、中药实验研究、中药新资源开发等提供理论线索和数据支持.方法:在对数据等级编码基础上,采用spearman等级相关法对《中华本草》中8 356味具有四气属性中药的药性规律进行分析.结果:四气与辛、甘2味存在显著正相关(P＜0.01);与苦、淡2味存在显著负相关(P＜0.01);与脾、胃、肾三经存在显著正相关(P＜0.01);与大肠、心、膀胱、胆、小肠、肺六经(按相关性递减排序)存在显著负相关(P＜0.01);与毒性之间存在显著正相关(P＜0.01).结论:药性越“热”则越可能具有辛、甘2味,越常入脾、胃、肾三经,其毒性更大;药性越“寒”则越可能具有苦、淡2味,越常人大肠等六经.

Four properties law of nature data of Chinese materia medica in "Chinese herbal medicine (CHM)"

Objective: In order to provide theoretical clues and data support for the use of Chinese medicine clinical drug, experimental study of Chinese materia medica and development of new resources of Chinese materia medica, the four properties as the core, the relationships of property, flavor, channel tropism and toxicity in nature data of Chinese materia medica were analyzed.Method: The spearman rank correlation method was employed to analyze 8 356 Chinese drugs with characteristic of four properties from "Chinese Herbal Medicine" based on data level coding.Result: It was discovered that four properties showed significant positive correlations with tastes of "pungent and sweet", channels of "spleen", "stomach", "kidney" and "toxicity", but also showed significant negative correlations with tastes of "bitter" and "light" and six channels such as "large intestine", "heart", "bladder", "gallbladder", "small intestine" and "lung" (in descending order of correlation ) (P<0.01).Conclusion: It was indicated that the more hot the Chinese medicine nature, the more possible it contained "toxicity", tastes of "pungent" and "sweet", and the more possible it was belong to channels of "spleen", "stomach" and "kidney".As well, the more cold the Chinese medicine nature, the more possible it contained tastes of "bitter" and "light", and the more possible it was belong to six channels such as "large intestine", etc.