2型糖尿病患者血清甲状腺激素含量分析

目的:探讨2型糖尿病（DM）患者血清甲状腺激素（TH）含量的变化及其临床意义。方法:对我院152例2型糖尿病患者测定空腹血糖（FPG）及测定血清游离三碘甲状腺原氨酸（FT₃）、游离甲状腺素（FT₄）、反三碘甲状腺原氨酸（rT₃）及促甲状腺激素（TSH）水平,并与62例正常人作比较。根据空腹血糖（FPG）水平,将糖尿病患者分为三组:血糖轻度增高组（A）（FPG≥6.1mmol/L且<8.8mmol/L）;血糖中度增高组（B）（FPG≥8.8mmol/L且<13.4mmol/L）;血糖重度增高组（C）（FPG≥13.4mmol/L）。结果:2型糖尿病患者血糖轻度及中度增高组血清FT₃水平与正常组比较无显著性差异（p>0.05）;血糖重度增高组FT₃水平显著低于正常对照组（p<0.05）,血糖重度增高组血清rT₃平显著高于正常组（p<0.01）。FT₄、及TSH水平与正常组比较无显著性差异（p>0.05）。血清FT₃水平随着血糖水平增高而呈降低的趋势。结论:2-型糖尿病患者血清甲状腺激素检测结果主要表现为FT3降低,降低程度与疾病严重程度一致,血清甲状腺激素检测对2型糖尿病患者糖代谢的评估和控制具有重要临床意义。

Analysis and Determination of Serum Thyroid Hormone(TH)Content in Type 2 Diabetes Mellitus(2-DM)Patients

Objective:To investigate the changes of serum thyroid hormone（TH） content with type 2 diabetes mellitus（2-DM） patients and its clinical significance.Methods:Fasting plasma glucose（FPG） and serum free triiodothyronine 3（FT₃）,free thyroxine（FT₄）,triiodothyronine anti-3 （rT₃） and thyroid stimulating hormone（TSH） levels were measured in 152 patients with 2-DM and 62 normal controls in our hospital According to the levels of FPG,The patients with 2-DM were divided into three groups:mildly raised blood glucose group（A）（FPG≥6.1mmol/L and<8.8mmol/ L）;moderately raised blood glucose group（B）（FPG≥8.8mmol/L and<13.4mmol/L）;severely raised blood glucose group（C）（FPG≥13.4mmol/ L）.Results:There was no significant difference in the serum FT₃ levels between patients with mildly and moderately raised blood glucose and normal controls（p>0.05）,but that of patients with severely raised blood glucose were lower significantly than the health controls（p<0.05）.The serum rT3 levels in patients with severely raised blood glucose were higher significantly than the health controls（p<0.01）.The serum FT₃ levels in patients with 2-DM showed the reduced tendency with blood glucose ascending.Conclusion:The serum TH levels in patients with 2-DM show mainly the reduction of FT₃,and the degree of reduction is consistent with disease severity.The measurement of serum thyroid hormone levels in patients with 2-DM diabetes has important clinical significance in the assessment and control of glucose metabolism of patients with 2-DM.