| Cyclooxygenase 2 polymorphism and colorectal cancer： -765G〉C variant modifies risk associated with smoking and body mass index |
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| 引用本文： | Xing LL,Wang ZN,Jiang L,Zhang Y,Xu YY,Li J,Luo Y,Zhang X. Cyclooxygenase 2 polymorphism and colorectal cancer： -765G〉C variant modifies risk associated with smoking and body mass index[J]. World journal of gastroenterology : WJG, 2008, 14(11): 1785-1789. DOI: 10.3748/wjg.14.1785 |
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| 作者姓名： | Xing LL Wang ZN Jiang L Zhang Y Xu YY Li J Luo Y Zhang X |
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| 作者单位： | Li-Li Xing（Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China） ;Zhen-Ning Wang（Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China） ;Li Jiang（Department of Medical Genomics of China Medical University, Shenyang 110001,Liaoning Province, China） ;Yong Zhang（Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China） ;Ying-Ying Xu（Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China） ;Juan Li（Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China） ;Yang Luo（Department of Medical Genomics of China Medical University, Shenyang 110001,Liaoning Province, China） ;Xue Zhang（Department of Medical Genomics of China Medical University, Shenyang 110001,Liaoning Province, China） ; |
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| 基金项目： | Supported by Program for New Century Excellent Talents from University, No. NCET-06-0296 |
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| 摘 要： | AIM： To explore whether cyclooxygenase 2 （COX-2） -765G〉C polymorphism is associated with susceptibility of colorectal cancer （CRC） and to evaluate the risk of colorectal cancer in relation to environmental exposures and polymorphism. METHODS： We conducted a case-control study of 137 patients with colorectal cancer and 199 cancerfree controls in northeast China. Multivariate logistic regression analysis was performed to calculate the adjusted odds ratio （OR） and 95% confidence interval （95% CI）. RESULTS： The -765G〉C polymorphism was not independently associated with CRC risk. However, risk associated with the polymorphism differed by smoking and body mass index （BMI）. Smoking and BMI associated risks were stronger among those with -765GG genotype, showing that smokers had a 2.682-fold greater risk of CRC than nonsmokers （51/43 vs 68/126, P = 0.006）. Compared to those with a normal body mass index （BMI 18.5-22.9）, those with overweight （BMI 23-24.9） had a 3.909-fold higher risk of CRC （OR = 3.909, 95% CI = 2.081-7.344; P 〈 0.001）, while those with obesity （BMI 〉 25） had a 2.031- fold higher risk of CRC （OR = 1.107, 95% CI = 1.107-3.726; P = 0.022）. is not associated with an increased risk of CRC, -765GG genotype appears to be related to an increased risk in the presence of smoking and higher BMI.
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| 关 键 词： | 直肠癌 多态现象 抽烟 发病机制 |
| 收稿时间： | 2007-05-10 |
Cyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index |
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| Xing Li-Li,Wang Zhen-Ning,Jiang Li,Zhang Yong,Xu Ying-Ying,Li Juan,Luo Yang,Zhang Xue. Cyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index[J]. World journal of gastroenterology : WJG, 2008, 14(11): 1785-1789. DOI: 10.3748/wjg.14.1785 |
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| Authors: | Xing Li-Li Wang Zhen-Ning Jiang Li Zhang Yong Xu Ying-Ying Li Juan Luo Yang Zhang Xue |
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| Affiliation: | 1. Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
2. Department of Medical Genomics of China Medical University, Shenyang 110001,Liaoning Province, China |
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| Abstract: | AIM: To explore whether cyclooxygenase 2 (COX-2) -765G＞C polymorphism is associated with susceptibility of colorectal cancer (CRC) and to evaluate the risk of colorectal cancer in relation to environmental exposures and polymorphism.METHODS: We conducted a case-control study of 137 patients with colorectal cancer and 199 cancer-free controls in northeast China. Multivariate logistic regression analysis was performed to calculate the adjusted odds ratio (OR) and 95% confidence interval (95% CI).RESULTS: The -765G＞C polymorphism was not independently associated with CRC risk. However, risk associated with the polymorphism differed by smoking and body mass index (BMI). Smoking and BMI associated risks were stronger among those with -765GG genotype, showing that smokers had a 2.682-fold greater risk of CRC than nonsmokers (51/43 vs 68/126, P = 0.006). Compared to those with a normal body mass index (BMI 18.5-22.9), those with overweight (BMI 23-24.9) had a 3.909-fold higher risk of CRC (OR = 3.909, 95% CI = 2.081-7.344; P ＜ 0.001), while those with obesity (BMI ＞ 25) had a 2.031- fold higher risk of CRC (OR = 1.107, 95% CI = 1.107-3.726; P = 0.022).CONCLUSION: Although COX-2 -765G＞C polymorphism is not associated with an increased risk of CRC, -765GG genotype appears to be related to an increased risk in the presence of smoking and higher BMI. |
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| Keywords: | Colorectal cancer Cyclooxygenase 2 Polymorphism Smoking Body mass index |
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