| 舒脉宁注射液对大鼠脑缺血再灌注损伤保护作用的实验研究 |
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| 引用本文： | 王同聚,杨红亚,陈维亮,田松朝,郭镔荣. 舒脉宁注射液对大鼠脑缺血再灌注损伤保护作用的实验研究[J]. 天津中医药, 2012, 29(1): 72-74 |
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| 作者姓名： | 王同聚 杨红亚 陈维亮 田松朝 郭镔荣 |
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| 作者单位： | 解放军第371中心医院,新乡,453000 |
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| 摘 要： | [目的]探讨舒脉宁注射液(SHUMN)对脑缺血再灌注损伤的保护作用。[方法]采用大鼠全脑缺血再灌注损伤模型,观察脑缺血前后血浆一氧化氮(NO)、内皮素(ET)和脑组织钙及含水量的变化。[结果]脑缺血再灌注期血浆NO、ET和脑组织钙及含水量显著升高(P<0.05),使用舒脉宁注射液后,血浆NO、ET和脑组织钙及含水量明显降低。[结论]舒脉宁注射液对脑缺血再灌注损伤确有保护作用。
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| 关 键 词： | 舒脉宁注射液 脑缺血再灌注损伤 一氧化氮 内皮素 |
| 收稿时间： | 2011-09-10 |
Protective effect of SHUMAINING injection against ischemia-reperfusion injury of brain in rats |
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| WANG Tong-ju,YANG Hong-y,CHEN Wei-liang,TIAN Song-chao and GUO Bin-rong. Protective effect of SHUMAINING injection against ischemia-reperfusion injury of brain in rats[J]. Tianjin Journal of Traditional Chin Medicine, 2012, 29(1): 72-74 |
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| Authors: | WANG Tong-ju YANG Hong-y CHEN Wei-liang TIAN Song-chao GUO Bin-rong |
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| Affiliation: | (No.371 Central Hospital of the Chinese People’s Liberation Army,Xinxiang 453000,China) |
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| Abstract: | [Objective] To investigate the protective effect of SHUMAINING injection against cerebral ischemia-reperfusion injury. [Methods] The cerebral ischemia-reperfusion injury was induced in rats. Then the blood NO, ET and brain Ca2+, brain water content of rats were respectively observed. [Results] In the stage of cerebral ischemia-reperfusion injury, all the blood NO, ET and brain Ca2+ and brain water content of rats increased significantly. After treating with SHUMAINING injection, all these parameters decreased significantly when compared with that before. [Conclusion] The protective effect of SHUMAINING injection in rats with cerebral ischemia-reperfusion injury is definite. |
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| Keywords: | SHUMAINING injection cerebral ischemia-reperfusion injury nitric oxide endothelin-1 |
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