缺血性中风气虚证出现频率与神经功能缺损程度的关系初探

目的]通过比较气虚证出现频率不同分组间神经功能缺损评分的差异,探讨缺血性中风气虚证出现频率与神经功能缺损程度的关系。方法]选取缺血性中风发病72h内患者605例,动态采集患者发病1-14 d及发病28、90 d时《缺血性中风证候要素诊断量表》、美国国立卫生研究院卒中量表(NIHSS)评分,根据气虚证出现的时点频率将患者分为气虚证出现时点≤8个组(298例),气虚证出现时点>8个组(307例)。比较气虚证出现频率不同分组间神经功能缺损评分的差异。结果]各时点两组神经功能缺损程度评分差异均有统计学意义(P<0.01);两组组内各时点神经功能缺损程度评分比较,差异均有统计学意义(P=0.000),随时间的延后,两组神经功能缺损程度评分均逐渐降低。两组发病14 d与入组当天神经功能缺损程度评分差值比较,差异有统计学意义(P<0.05),气虚证出现时点≤8个组发病14 d与入组当天神经功能缺损程度评分差值大。结论]缺血性中风气虚证出现时点多的患者神经功能缺损程度较气虚证出现时点少的患者更重,且气虚证出现时点多的患者发病14 d时神经功能缺损程度的改善无气虚证出现时点少的患者明显,积极扶助正气治疗对改善中风病的神经功能缺损程度具有重要作用。

Study on the correlation between frequency of Qi deficiency and neurological deficit in patients with ischemic stroke

Objective] To compare the effect of Tongbu Xinbao capsules (TBXBCs) and Buyi Qiangxin tablets (BYQXTs) on chronic congestive heart failure (CHF) and observe the level of plasma endothelin (ET), nitric oxide (NO) and brain natriuretic peptide (BNP) in CHF patients.Methods] The 120 CHF patients with heart and kidney Yang deficiency and internal water and dampness retention were selected and using a randomized single blind method they were divided into treatment group and control group. The patients in both groups were given routine Western medicine, but TBXBCs were added in treatment group and BYQXTs in control group. Two months was one course. TCM syndrome before and after treatment, quality of life, heart function, heart color Doppler ultrasonic echocardiography, plasma ET, NO, BNP of two groups were observed.Results] Compared with control group, the heart failure symptoms, quality of life and heart function were significantly improved in treatment group (P<0.05). The ejection fraction (EF) and the left ventricular end-systolic dimension (LVESD) were improved significantly (P<0.05); NO, ET and BNP were significantly decreased in treatment group (P<0.05).Conclusion] TBXBCs can improve symptoms and quality of life in CHF patients and can significantly inhibit the increasing of plasma ET, NO levels, decrease the level of BNP at the same time. It can also significantly improve and adjust the CHF hemodynamics.