| 肌骨共病视阈下肌骨共减综合症的生物学机制探究 |
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| 引用本文： | 徐帅,余锋,徐道明,赵春竹,吴文忠.肌骨共病视阈下肌骨共减综合症的生物学机制探究[J].中国骨质疏松杂志,2021(3):446-449. |
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| 作者姓名： | 徐帅 余锋 徐道明 赵春竹 吴文忠 |
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| 作者单位： | 1.淮阴师范学院体育学院，江苏 淮安 223300
2.南京中医药大学附属医院，江苏 南京 210029
3.青岛大学附属医院，山东 青岛 266000 |
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| 基金项目： | 江苏省教育科学“十三五”规划重点课题（T-a/2020/04）；江苏省卫生健康委员会（H2019093）；江苏省中医院院级课题（Y2019CX09、Y2019CX30）；省级中医康复示范（江苏）中心建设项目（K2017ykf18）; 江苏省卫生健康委干部保健局（BJ16019）；教育部人文社会科学研究青年基金（19YJC890056） |
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| 摘 要： | 肌少症和骨质疏松症为常见的衰老性疾病,肌骨共病为肌骨共减综合症提供新的研究基础。肌肉分泌IGF-1、MSTN、OG、OCN、FAM5C、Irisin、FGF-2、IL-6、IL-7、IL-15和MMP-2调节肌骨共减综合症视阈下骨骼质量;骨骼分泌IGF-1、SOST、VEGF、OCN、MGF和HGF调节肌骨共减综合症视阈下肌肉质量。本文将通过探析和梳理肌少症、骨质疏松症的流行病学和生理功能特点,为共病视阈下肌骨共减综合症提供新的导向。
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| 关 键 词： | 共病 肌少症 骨质疏松症 肌骨共减综合症 |
Study on the biological mechanism of musculoskeletal comorbidities with subthreshold osteosarcopenia |
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| XU Shuai,YU Feng,XU Daoming,ZHAO Chunzhu,WU Wenzhong.Study on the biological mechanism of musculoskeletal comorbidities with subthreshold osteosarcopenia[J].Chinese Journal of Osteoporosis,2021(3):446-449. |
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| Authors: | XU Shuai YU Feng XU Daoming ZHAO Chunzhu WU Wenzhong |
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| Institution: | 1. Institute of Physical Education, Huaiyin Normal University, Huaian 223300, Jiangsu, China
2. The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu, China
3. The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China |
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| Abstract: | Sarcopenia and osteoporosis become common aging diseases. Musculoskeletal comorbidities provide a basis for the study of osteosarcopenia. IGF-1, MSTN, OG, OCN, FAM5C, Irisin, FGF-2, IL-6, IL-7, IL-15, and MMP-2 secreted by the muscle regulate the bone mass under the visual threshold of osteosarcopenia. IGF-1, SOST, VEGF, OCN, MGF, and HGF secreted by bone regulate the muscle under the visual threshold of osteosarcopenia. This article will provide a new guide for the osteosarcopenia by the analysis and combination of sarcopenia and osteoporosis epidemiological and physiological functions. |
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| Keywords: | comorbidity sarcopenia osteoporosis osteosarcopenia |
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