新型超声诊疗一体机VINNO70的空化调控功能及声学测量

目的 对新型超声诊疗一体机VINNO 70的空化调控功能，以及对超声频率、脉冲宽度、脉冲重复频率及机械指数等声学参数进行测量，以及VFlash超声治疗模式下的声场分布及自适应可变焦域技术。方法 利用薄膜水听器法测量各项参数的实测值，验证其与仪器显示值的一致性。其中，重点测量在距换能器表面2cm和5cm位置感兴趣区（ROI）内的峰值负压值，然后计算对应的机械指数（MI），并与MI仪器显示值对比。结果 超声线阵探头X4-12L与凸阵探头S1-8C在超声频率、脉冲宽度、脉冲重复频率参数的实测值与仪器显示值完全一致。峰值负压值的声场分布显示，自适应可变焦域区具有明显的超声弱聚焦性能，ROI内微泡击破明显。但是MI实测值与仪器显示值有较大差距（58%-267%），而且频率与测量距离等均可以影响MI值。结论 VINNO 70超声仪准确调控多个空化相关参数，自适应可变焦域技术可以明显靶向击破ROI区内的微泡。MI实测值与显示值差别较大，因此，实施治疗时应该以实测值为准。

Cavitation Modulation and Acoustic Measurement of VINNO 70 Ultrasound Theranostic System

Objectives The study is to investigate the cavitation regulation of VINNO 70 integrated ultrasound theranostic system, including the measurements of frequency (f), pulse length (PL), pulse repetition frequency (PRF) and mechanic index (MI), as well as the adapted weakly focusing in therapeutic VFlash mode. Methods Membrane hydrophone and oscilloscope were used to measure the above parameters and MI distribution. The relationship of the setting MI and actual value was detected. Furthermore, the influence of f and distance to transducer on MI was also explored. Results It showed that the actual value of f, PL and PRF for the linear array probe X4-12L and convex array probe S1-8C were consistent with setting value. The acoustic distribution and microbubble destruction demonstrated that the VFlash mode could weakly focus on the ROI. However, there was some difference between the setting and actual value of MI. And MI was affected by the f and distance to the transducer. Conclusion VINNO 70 integrated ultrasound theranostic system can regulate cavitaion by f, PL, PRF and so on. And VFlash mode can weakly focused on the ROI resulting in regional targeting microbubble destruction.