肿瘤“瘀毒”病机理论诠释

[目的]通过对"瘀毒"病机理论的诠释,为中医临床抗肿瘤治疗提供理论基础和指导方向。[方法]通过查阅肿瘤相关中医学文献,结合现代分子生物学研究,探讨"瘀毒"理论中"瘀"和"毒"的含义及成因,对"瘀毒"理论进行诠释,并提出相应治疗策略。[结果]肿瘤"瘀毒"病机理论中的"瘀"指的是体内物质淤积、阻滞的状态,多由正虚和邪实共同导致。"毒"指的是具有强烈致病性,容易导致疾病恶化的致病因素,多由"瘀"蕴久而生。在微观层面,肿瘤微环境的形成及其组分的改变是"瘀毒"的典型特征。根据"瘀毒"理论,匡扶正气,求本溯源;探寻邪实,不忘瘀血;瘀毒同治,通达机变是肿瘤的中医治疗原则。[结论]"瘀毒互结"是肿瘤发生发展的核心,依据"瘀毒"理论衍生的治则治法可以指导肿瘤的治疗,值得同道借鉴。

Interpretation of the Etiology of Tumor Stasis-toxin

[Objective] To provide theoretical basis and guiding direction for the clinical research on anti-tumor of traditional Chinese medicine(TCM)through explaining the pathogenesis theory of "stasis-toxin".[Methods] This article combined the theory of TCM and molecular biology,discussed the meaning and causes of"stasis"and"toxin"and interpreted"stasis-toxin"in modern medicine. Based on the above theory,new treatment strategy was proposed.[Results] This paper clarifies that "stasis"is a state of material accumulation and blockage in the body caused by the combination of weakened body resistance and pathogenic factors."Toxin"is a pathogenic factor generated by the long-term existence of"stasis"which has strong pathogenicity and can easily lead to the deterioration of the disease. From the perspective of molecular biology,the change of tumor microenvironment is the microscopic manifestation of "stasis-toxin". Thereby,the principles of TCM oncology treatment were proposed: Cultivating Qi,tracing the origin,exploring the pathological factors and blood-stasis,treating stasis and toxicity together. [Conclusion] Combining TCM theory and molecular biology,this paper discussed the theory of"stasis-toxin"in tumor and provided a further supplement to anti-tumor theory of TCM,which has a certain guiding significance for clinical treatment.