| Lipid accumulation and protein modifications of Bruch’s membrane in age-related macular degeneration |
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| 引用本文： | Tomaso Caporossi,Ruggero Tartaro,Giancarlo Albani,Francesco Bar,Fabrizio Giansanti,Stanislao Rizzo. Lipid accumulation and protein modifications of Bruch’s membrane in age-related macular degeneration[J]. 国际眼科, 2021, 14(5): 774-776. DOI: 10.18240/ijo.2021.05.20 |
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| 作者姓名： | Tomaso Caporossi Ruggero Tartaro Giancarlo Albani Francesco Bar Fabrizio Giansanti Stanislao Rizzo |
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| 作者单位： | Department of Surgical and Translational Medicine, Eye Clinic, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence 50139, Italy,Department of Surgical and Translational Medicine, Eye Clinic, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence 50139, Italy,Department of Surgical and Translational Medicine, Eye Clinic, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence 50139, Italy,Department of Surgical and Translational Medicine, Eye Clinic, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence 50139, Italy,Department of Surgical and Translational Medicine, Eye Clinic, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence 50139, Italy and Department of Surgical and Translational Medicine, Eye Clinic, University of Florence, Azienda Ospedaliera Universitaria Careggi, Florence 50139, Italy; Department of Ophthalmology, Catholic University of Sacred-Heart Foundation “Policlinico Universitario A. Gemelli” IRCCS, Rome 00168, Italy |
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| 摘 要： | Age-related macular degeneration (AMD) is a progressive retinal disease, which is the leading cause of blindness in western countries. There is an urgency to establish new therapeutic strategies that could prevent or delay the progression of AMD more efficiently. Until now, the pathogenesis of AMD has remained unclear, limiting the development of the novel therapy. Bruch’s membrane (BM) goes through remarkable changes in AMD, playing a significant role during the disease course. The main aim of this review is to present the crucial processes that occur at the level of BM, with special consideration of the lipid accumulation and protein modifications. Besides, some therapies targeted at these molecules and the construction of BM in tissue engineering of retinal pigment epithelium (RPE) cells transplantation were listed. Hopefully, this review may provide a reference for researchers engaged in pathogenesis or management on AMD.
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| 关 键 词： | Bruch’s membrane lipid accumulation protein modifications therapy |
| 收稿时间： | 2020-09-17 |
| 修稿时间： | 2020-11-26 |
Via pars plana anterior iris enclavation IOL fixation |
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| Tomaso Caporossi,Ruggero Tartaro,Giancarlo Albani,Francesco Barc,Fabrizio Giansanti and Stanislao Rizzo. Via pars plana anterior iris enclavation IOL fixation[J]. International journal of ophthalmology, 2021, 14(5): 774-776. DOI: 10.18240/ijo.2021.05.20 |
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| Authors: | Tomaso Caporossi Ruggero Tartaro Giancarlo Albani Francesco Barc Fabrizio Giansanti Stanislao Rizzo |
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| Affiliation: | 1Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. |
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| Abstract: | AIM: To describe a via pars plana anterior iris enclavation intraocular lens (IOL) fixation techniqueMETHODS: A total of 35 consecutive aphakic vitrectomised patients (average age 71.12±10.12y) underwent pars plana vitrectomy (PPV) and via pars plana anterior iris enclavation IOL fixation.RESULTS: The mean preoperative best corrected visual acuity (BCVA) was 0.11±0.14 logMAR, the mean postoperative BCVA was 0.07±0.11 logMAR. The preoperative mean spherical equivalent was 7.22±4.21 D. The final mean spherical equivalent was -0.25±0.15 D. No eyes had hypotony, retinal or choroidal detachment or endophthalmitis.CONCLUSION: This technique may be a safe and useful in the case of aphakia, and a prospective study would be useful to confirm this findings. |
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| Keywords: | IOL luxation via pars plana vitrectomy cystoid macular edema iris enclavation IOL |
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