大黄附子汤治疗脓毒症伴胃肠功能紊乱临床研究

目的:观察大黄附子汤治疗对脓毒症患者胃肠功能恢复的临床疗效。方法:将100例脓毒症伴胃肠功能紊乱患者,按随机数字表法分为对照组和观察组各50例。对照组给予常规西药治疗,观察组在对照组的基础上加用大黄附子汤治疗。比较2组急性生理学及慢性健康评估Ⅱ(APACHEⅡ)评分、胃肠功能障碍评分、白细胞计数(WBC)、超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)及临床疗效、不良反应情况。结果:观察组总有效率为94.00%,对照组为80.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组胃肠功能障碍评分、APACHEⅡ评分均较治疗前明显降低(P<0.05),且观察组2项评分均低于对照组(P<0.05)。治疗后,2组WBC、hs-CRP、PCT水平均较治疗前明显降低(P<0.05),且观察组各项指标均低于对照组(P<0.05)。治疗期间所有患者均未出现明显不良反应情况。结论:在西医常规治疗的基础上,大黄附子汤可有效改善脓毒症伴胃肠功能紊乱患者的症状,临床疗效显著。

Clinical Study on Dahuang Fuzi Tang for Sepsis Complicated with Gastrointestinal Dysfunction

Objective:To observe the clinical effect of Dahuang Fuzi tang on the recovery of gastrointestinal function in patients with sepsis.Methods:A hundred patients with sepsis complicated with gastrointestinal dysfunction were divided into the control group and the observation group according to the random number table method,50 cases in each group.The control group was given conventional western medicine for treatment,and the observation group was additionally treated with Dahuang Fuzi tang based on the treatment of the control group.The score of Acute Physiology and Chronic Health Evaluation II(APACHE II),score of gastrointestinal dysfunction,white blood cell count,hypersensitive C-reactive protein(hs-CRP),procalcitonin,clinical effect and adverse reactions were compared between the two groups.Results:The total effective rate was 94.00%in the observation group and 80.00%in the control group,the difference being significant(P<0.05).After treatment,the scores of gastrointestinal dysfunction and APACHE II in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the above two scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of white blood cell,hs-CRP and procalcitonin in two groups were significantly decreased when compared with those before treatment(P<0.05),and the above levels in the observation group were lower than those in the control group(P<0.05).No obvious adverse reactions occurred in all patients during the treatment.Conclusion:The application of Dahuang Fuzi tang based on conventional western medicine can effectively improve the clinical symptoms and gastrointestinal dysfunction of patients,with significant clinical effect.