| 狼毒大戟根中的萜类成分研究 |
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| 引用本文： | 陈虎,历明辉,陶平德,陈黎.狼毒大戟根中的萜类成分研究[J].中国现代中药,2021,23(1):44-47. |
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| 作者姓名： | 陈虎 历明辉 陶平德 陈黎 |
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| 作者单位： | 湖北医药学院 附属太和医院 药学部，湖北十堰442000 |
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| 基金项目： | 2018年太和医院院级项目（2018JJXM111） |
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| 摘 要： | 目的:研究狼毒大戟Euphorbia fischeriana根中的萜类成分。方法:利用硅胶、MCI、ODS、Sephadex LH-20柱色谱及半制备高效液相色谱法(HPLC)等分离手段对狼毒大戟根中的萜类成分进行分离纯化,根据理化性质、波谱学数据分析鉴定化合物结构。结果:从狼毒大戟根的80%丙酮提取物中分离鉴定了7个萜类化合物,包括5个二萜类化合物和2个三萜类化合物,分别鉴定为7-羰基脱氢松香酸(1)、trogopteroid F(2)、陶塔二酚(3)、18-羟基弥罗松酚(4)、19-羟基弥罗松酚(5)、环木波罗-22-烯-3β,25-二醇(6)和羽扇豆醇(7)。结论:除了化合物6和7,其余化合物均为首次从狼毒大戟中分离得到。
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| 关 键 词： | 狼毒大戟 二萜 三萜 7-羰基脱氢松香酸 trogopteroid F 陶塔二酚 18-羟基弥罗松酚 19-羟基弥罗松酚 |
| 收稿时间： | 2019/12/30 0:00:00 |
Terpenoids Isolated from Roots of Euphorbia fischeriana |
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| CHEN Hu,LI Ming-hui,TAO Ping-de,CHEN Li.Terpenoids Isolated from Roots of Euphorbia fischeriana[J].Modern Chinese Medicine,2021,23(1):44-47. |
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| Authors: | CHEN Hu LI Ming-hui TAO Ping-de CHEN Li |
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| Institution: | (Department of Pharmacy,Taihe Hospital,Hubei University of Medicine,ShiyanChina) |
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| Abstract: | Objective:To investigate the terpenoids from the roots of Euphorbia fischeriana.Methods:The compounds were isolated and purified by silica gel,MCI,ODS,Sephadex LH-20,and semi-preparative high performance liquid chromatography(HPLC)repeatedly,and elucidate according to their physicochemical properties and spectroscopics.Results:Seven known compounds,including five diterpenoids and two triterpenoids were isolated from 80%acetone extracts of roots of E.fischeriana and identified as 7-oxodehydroabietic acid(1),trogopteroid F(2),totaradiol(3),18-hydroxyferruginol(4),19-hydroxyferruginol(5),cycloart-22-ene-3β,25-diol(6)and lupeol(7).Conclusion:Except for compounds 6 and 7,all of the compounds were isolated from this genius for the first time. |
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| Keywords: | Euphorbia fischeriana Steud diterpenoid triterpenoid 7-oxodehydroabietic acid trogopteroid F totaradiol 18-hydroxyferruginol 19-hydroxyferruginol |
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