复方羚角降压片联合福辛普利治疗原发性高血压的临床研究

目的探讨复方羚角降压片联合福辛普利钠片治疗原发性高血压的临床疗效。方法选取2019年1月—2019年12月在河南省中医药研究院附属医院就诊的138例原发性高血压患者,随机分为对照组和治疗组,每组各69例。对照组口服福辛普利钠片,10 mg/次,1次/d;治疗组在对照组的基础上口服复方羚角降压片,3片/次,3次/d。两组患者均治疗12周。观察两组患者临床疗效,比较治疗前后两组患者血压变异性,血清血管内皮生长因子(VEGF)、内皮素1(ET-1)和一氧化氮(NO)、超敏C反应蛋白(hs-CRP)和白细胞介素6(IL-6)水平。结果治疗后,治疗组总有效率为94.20%,显著高于对照组的82.61%(P<0.05)。治疗后,两组24 h收缩压(SBP)、24 h舒张压(DBP)、收缩压变异性(SBPV)和舒张压变异性(DBPV)均显著降低(P<0.05),与对照组相比,治疗组降低更显著(P<0.05)。治疗后,两组VEGF、ET-1、hs-CRP和IL-6水平均显著下降,而NO水平显著升高(P<0.05),且治疗组这些指标水平显著优于对照组(P<0.05)。结论复方羚角降压片联合福辛普利钠片治疗原发性高血压疗效显著,能有效改善患者血管内皮细胞功能和炎症状态,具有一定的临床推广应用价值。

Clinical study on Compound Lingjiao Jiangya Tablets combined with fosinopril in treatment of primary hypertension

Objective To observe the clinical effect of Xiangsha Pingwei Granules combined with itopride in treatment of functional dyspepsia. Methods A total of 83 patients with functional dyspepsia treated in People''s Hospital of Chongqing Banan District from June 2018 to June 2019 were selected as the research subjects, and the patients were divided into control group (41 cases) and observation group (42 cases) according to the treatment methods. Patients in the control group were po administered with Itopride Hydrochloride Dispersible Tablets, 50 mg/time, three times daily. Patients in the observation group were po administered with Xiangsha Pingwei Granules on the basis of control group, 1 bag/time, twice daily. Patients in two groups were treated for 30 d. The clinical efficacy of two groups was observed, and the levels of gastrointestinal hormones, electrical rhythm, quality of life and clinical scores of the two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 97.6%, which was significantly higher than 65.8% of the control group, and the difference between two groups was statistically significant (P < 0.05). After treatment, the serum levels of MTL, GAS, SP in two groups were significantly increased (P < 0.05), and the gastrointestinal hormone level in observation group was significantly higher than those in control group (P < 0.05). After treatment, the gastric body, greater curvature, lesser curvature, and antrum of the stomach electric rhythm in two groups were significantly decreased (P < 0.05), and the electric rhythm in observation group was significantly lower than that in control group (P < 0.05). After treatment, the SF-36 score in two groups was significantly increased (P < 0.05), and the observation group was significantly higher than the control group (P < 0.05). After treatment, the scores of feeling of fullness, early satiety, epigastric pain, heartburn and total scores in two groups were significantly decreased (P < 0.05), and the clinical symptom score of observation group was significantly lower than those of control group (P < 0.05). Conclusion Xiangsha Pingwei Granules combined with itopride has significant efficacy in treatment of patients with functional dyspepsia, which can improve clinical symptoms, improve gastric motility function and quality of life of patients, and is worthy of promotion.