扩散峰度成像在脑电图表现正常儿童特发性全面性癫痫的研究

目的:分析脑电图(EEG)结果正常的特发性全面性癫痫(IGE)患儿扩散峰度成像(DKI)的各向特征值.方法:将头皮EEG结果正常的9例IGE患儿与18例年龄、性别匹配的正常对照(NC)组儿童的头部DKI影像,通过基于体素分析方法估计,DKI参数各向异性分数(FA)、平均扩散吸系数(MD,)及平均峰度值(MK),MD包括...

Diffusion kurtosis imaging study in EEG-negative idiopathic generalized epilepsy in children

Objective:To evaluate Electroencephalogram(EEG)-negative idiopathic generalized epilepsy(IGE)in children using diffusion kurtosis imaging(DKI)with the indices of fractional anisotropy(FA),mean diffusion(MD)and mean kurtosis(MK).Methods:DKI images were obtained from nine IGE children without interictal epileptiform discharges(IED)recorded from EEG,18 age-and sex-matched children were enrolled as the normal control(NC)group and compared with the IGE group.FA,MD(MD⊥、MD∥)and MK(MK⊥、MK∥)were estimated through voxel-based analysis.Statistics was compared among the IGE group and the NC group.Results:The reduction of FA were found in the left cerebrum of white matter(WM)(391),brodmann area 47(114)and sub-gyral area(100).The increase of MD were found in the left cerebrum,temporal lobe of WM(362)and middle temporal gyrus(240).The significant differences of MK∥were in the sub-lobar area of left cerebrum(66).Conclusion:The indices of DKI could detect WM and GM abnormalities in EEG-negative IGE children,and can provide imaging information support in treatment with antiepileptic drugs and in follow-up study.