补肺益肾汤联合舒利迭治疗肺肾亏虚型慢性阻塞性肺疾病临床研究

目的:观察补肺益肾汤联合舒利迭治疗肺肾亏虚型慢性阻塞性肺疾病的临床疗效.方法:将80例肺肾亏虚型慢性阻塞性肺疾病患者按随机数字表法分为研究组和对照组各40例.2组均给予常规西医治疗,对照组给予舒利迭治疗,研究组在对照组基础上联合补肺益肾汤治疗,均治疗4周.比较2组临床疗效,评价改良呼吸困难指数(mMRC)评分、圣乔治医...

Clinical Study on Bufei Yishen Tang Combined with Seretide for COPD of Lung andKidney Depletion Type

Objective: To observe the clinical effect of the therapy of Bufei Yishen tang combined with seretide on the treatment of chronic obstructive pulmonary disease of lung and kidney depletion type. Methods: A total of 80 chronic obstructive pulmonary disease patients of lung and kidney depletion type were divided into the study group and the control group according to the random number table method,40 cases in each group. Both groups were given conventional western medicine treatment,and the control group was additionally treated with seretide;the study group was additionally treated with Bufei Yishen tang based on the treatment of the control group. The treatment lasted for four weeks. The clinical effect was compared between the two groups;the changes in the scores of modified Medical Research Council(mMRC) and the St.George’s Respiratory Questionaire(SGRQ) were evaluated;the changes in the levels of interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), Copeptin and high mobility group B1(HMGB1) in serum were detected.Results: The total effective rate was 95.00% in the study group, higher than that of 77.50% in the control group, the difference being significant(P<0.05). After treatment, the mMRC scores, the activity scores, symptom scores and influence scores were decreased in the two groups when compared with those before treatment(P<0.05),and the above scores in the study group were lower than those in the control group(P<0.05). After treatment,the percentage of forced expiratory volume in the first second to the predicted value(FEV1%) in the control group was increased when compared with that before treatment(P<0.05);the exhalation volume in the first second(FEV1), FEV1% and FEV1/FVC in the study group were increased when compared with those before treatment, and were significantly higher than those in the control group, differences being significant(P<0.05). After treatment,the levels of IL-1β,TNF-α,Copeptin and HMGB1 in serum in the two groups were decreased when compared with those before treatment,and the above levels in the study group were lower than those in the control group, differences being significant(P<0.05). Conclusion: The therapy of Bufei Yishen tang combined with seretide can significantly improve activity endurance,quality of life,lung function,and reduce the levels of IL-1β,TNF-α,Copeptin and HMGB1 in serum in COPD patients with lung and kidney deficiency.