血清Lp-PLA2 GGT与冠心病及冠状动脉病变严重程度的相关性分析

目的分析血清脂蛋白相关磷脂酶A2(Lp-PLA2)、γ-谷氨酰转移酶(GGT)与冠心病(CHD)及冠状动脉病变严重程度的相关性。方法选择2018-06~2019-06于郑州大学第二附属医院心内科首次就诊的170例疑似CHD患者的临床资料,根据冠状动脉造影检查结果分为CHD组(103例)和非CHD组(67例)。检测患者血清Lp-PLA2、GGT水平,分析血清Lp-PLA2、GGT与CHD及冠状动脉病变严重程度的关系。结果CHD组Lp-PLA2、GGT、甘油三酯(TG)、低密度脂蛋白(LDL)、Gensin积分水平以及合并高血压、糖尿病人数比例显著高于非CHD组(P<0.05),而高密度脂蛋白(HDL)水平显著低于非CHD组(P<0.05)。Spearman相关分析结果显示,CHD患者血清Lp-PLA2、GGT水平与冠状动脉病变支数呈正相关(rs=0.681,P=0.000;rs=0.603,P=0.000)。Pearson相关分析结果显示,CHD患者血清Lp-PLA2、GGT水平与Gensin积分呈正相关(r=0.799,P=0.000;r=0.621,P=0.000)。多因素logistic分析结果显示,较高水平的Lp-PLA₂、GGT和LDL,以及合并高血压是促进CHD发生的危险因素(P<0.05);而较高水平的HDL是抑制CHD发生的保护因素(P<0.05)。结论较高水平的血清Lp-PLA2、GGT是促进CHD发生的危险因素,可较好地反映冠状动脉病变严重程度,可作为评估CHD发生、进展的可靠指标。

Analysis on the correlation of serum Lp-PLA2 and GGT with coronary heart disease and severity of coronary artery disease

Objective To analyze the correlation of serum lipoprotein-associated phospholipase A2(Lp-PLA2)and gamma-glutamyl transferase(GGT)with coronary heart disease(CHD)and severity of coronary artery disease.Methods The clinical data of 170 patients with suspected CHD who first visited the Department of Cardiology,the Second Affiliated Hospital of Zhengzhou University from June 2018 to June 2019 were selected,and the patients were divided into CHD group(103 cases)and non-CHD group(67 cases)according to the results of coronary angiography.The patients′serum levels of Lp-PLA2 and GGT were detected,and the relationship between serum Lp-PLA2,GGT and CHD and the severity of coronary artery disease was analyzed.Results The levels of Lp-PLA2,GGT,triglyceride(TG),low density lipoprotein(LDL)and Gensin score,and the proportion of the patients complicated with hypertension and diabetes in the CHD group were significantly higher than those in the non-CHD group(P<0.05),while the level of high density lipoprotein(HDL)was significantly lower than that in the non-CHD group(P<0.05).The results of Spearman correlation analysis showed that the serum levels of Lp-PLA2 and GGT in the CHD patients were positively correlated with the number of coronary artery lesions(rs=0.681,P=0.000;rs=0.603,P=0.000).The results of Pearson correlation analysis showed that the serum levels of Lp-PLA2 and GGT in the CHD patients were positively correlated with the Gensin score(r=0.799,P=0.000;r=0.621,P=0.000).The results of multivariate logistic analysis showed that higher levels of Lp-PLA2,GGT,LDL,and associated hypertension were the risk factors promoting the occurrence of CHD(P<0.05);and higher levels of HDL were the protective factors inhibiting the occurrence of CHD(P<0.05).Conclusion Higher levels of serum Lp-PLA₂ and GGT are the risk factors promoting the occurrence of CHD,which can better reflect the severity of coronary artery disease and can be used as a reliable indicator to evaluate the occurrence and progression of CHD.