TIP30蛋白在结直肠癌中的表达及意义

目的：探讨TIP30蛋白在结直肠癌中的表达及其意义。方法：采用S-P免疫组织化学染色法检测58例结直肠癌组织及20例结直肠黏膜慢性炎症组织中TIP30蛋白表达。结果：TIP30蛋白在结直肠癌组织中的阳性表达率为36.20%（21/58）,显著低于慢性炎症组的95%（19/20）,差异有显著性（P〈0.01）;TIP30蛋白在结直肠癌中的表达与淋巴结转移（P〈0.05）、浸润程度（P〈0.05）及预后（P〈0.05）有关。结论：TIP30的表达在结直肠癌中的发生、发展及预后中可能扮演着重要的角色。

Expression of Tat Interacting Protein 30 in Colorectal Carcinomas and Its Clinical Significance

Objective： To investigate expression of tat interacting protein 30（TIP30） in colorectal carcinoma and to explore the clinical significance.Methods： The expression of TIP30 protein in 58 specimens of colorectal carcinoma and 20 specimens of colorectal inflammatory tissue was detected with SP immunohistochemistry method.Results： The positive rate of TIP30 was 36.20%（21/58） in colorectal carcinoma,which was significantly lower than that of 95%（19/20） in colorectal inflammatory tissue（P〈0.01）.The expression of TIP30 protein in colorectal carcinoma related to lymph metastasis（P〈0.05）,and infiltration degree（P〈0.05）,and influenced prognosis of the disease（P〈0.05）.Conclusions： TIP30 protein may play an important role in the occurrence,development and prognosis of colorectal carcinoma.