“肺病及肠”动物模型建立的探索

目的:探索肺病及肠动物模型的最佳造模方案,为正式实验研究肺病及肠病理传变规律及机制做好模型复制的准备工作。方法:采用单纯烟熏法建立大鼠慢性支气管炎模型,将60只大鼠随机分成空白对照和模型组,观察两组大鼠体重和组织形态学变化。结果:模型组大鼠体重与正常对照组体重比较有差异(P0.05),模型组大鼠肺组织炎症发生率较空白对照组比较有差异(P0.05),模型组大鼠结肠组织炎症发生率较空白对照组比较有差异(P0.05)。结论:在大鼠慢性支气管炎模型的基础上出现了慢性炎症性肠炎的表现。

Exploration on Animal Model Replication of Lung Disease Involving Intestines

Objective:To explore the best method of animal model replication of lung disease involving intestines,which is prepared for formal experimental research on pathological processes and mechanism of the model.Methods:60 healthy SPF rats were randomly divided into blank-control and model groups,using simple smoking way to cause chronic bronchitis rat models,observing body weight and morphologic changes of the two groups.Results:It was found that there were significant differences(P<0.05)in rats’ body weights,incidence of inflammation of lung tissues and colonic tissues between the two groups.Conclusions:Manifestation of chronic inflammatory enteritis appeared on the basis of chronic bronchitis.