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眼针对脑缺血再灌注损伤大鼠血中SOD、MDA及BDNF含量的影响
引用本文:贾晓杰,谢鑫,王哲,王德山. 眼针对脑缺血再灌注损伤大鼠血中SOD、MDA及BDNF含量的影响[J]. 中华中医药学刊, 2012, 0(3): 486-488
作者姓名:贾晓杰  谢鑫  王哲  王德山
作者单位:沈阳市沈河区中医院;辽宁中医药大学
基金项目:国家重点基础研究发展计划(937计划)资助项目(2007CB512702)
摘    要:目的:观察眼针对脑缺血再灌注损伤大鼠血清超氧化物歧化酶(SOD)、丙二醛(MDA)和脑源性神经营养因子(BDNF)含量的影响,探讨眼针治疗脑缺血再灌注损伤的机制。方法:应用线栓法复制脑缺血再灌注损伤大鼠模型,采用眼针治疗,于再灌注后3、24、72h进行神经功能缺损评分,采用化学比色法测定大鼠血清SOD、MDA含量的变化。采用ELISA方法检测血中BDNF含量的变化。结果:与模型组比较,眼针组大鼠神经功能缺损评分明显下降,大鼠血清SOD含量增多,MDA含量减少,BDNF含量增多(P0.05)。结论:眼针具有明显改善大鼠脑缺血再灌注损伤的作用,其机制与大鼠血清SOD、MDA及BDNF变化有关。

关 键 词:眼针  脑缺血再灌注损伤  超氧化物歧化酶  丙二醛  脑源性神经营养因子

Effect of Eye Acupuncture Therapy on the Levels of Serum SOD and MDA in Rats with Cerebral Ischemia-reperfusion Injury
JIA Xiao-jie,XIE Xin,WANG Zhe,WANG De-shan. Effect of Eye Acupuncture Therapy on the Levels of Serum SOD and MDA in Rats with Cerebral Ischemia-reperfusion Injury[J]. Chinese Archives of Traditional Chinese Medicine, 2012, 0(3): 486-488
Authors:JIA Xiao-jie  XIE Xin  WANG Zhe  WANG De-shan
Affiliation:1.Shenhe District Chinese Medcine Hospital,Shenyang 110013,Liaoning,China; 2.Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)
Abstract:Objective:To investigate the effect of the eye acupuncture therapy on the levels of serum SOD,MDA and BDNF in rats with cerebral ischemia-reperfusion injury and the related mechanism.Methods:To establish the rat model of cerebral ischemia-reperfusion by suture method.The serum levels of SOD and MDA were measured by the chemical colorimetry.The method of ELISA was taken to detect the change of the BDNF levels.Results:Compared with the model group,the neurologic impairment score of the eye-acupuncture group reduced obviously.The serum levels of SOD and BDNF increasaed and those of MDA decreased in the eye-acupuncture group(P<0.05).Conclusion:The eye acupuncture therapy played a role in improving cerebral ischemia-reperfusion injury evidently and the mechanism was related to the alteration of serum SOD,MDA and BDNF levels.
Keywords:eye acupuncture  cerebral ischemia and reperfusion injury  SOD  MDA  BDNF
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