胃乐煎对HP感染模型大鼠胃病理组织的影响

目的:观察胃乐煎对HP感染模型大鼠胃病理组织的影响。方法:大鼠在去氧胆酸钠法造模基础上,灌胃丽珠维三联,清除大鼠胃內杂菌,再经口灌幽门螺杆菌(HP)复制HP感染模型,模型大鼠随机分组,观察胃乐煎对HP模型大鼠胃组织黏膜炎症指标、胃腺体厚度、腺体数量、壁细胞及主细胞的情况。结果:胃乐煎对HP模型大鼠体重有明显增加(P0.05～0.01);对HP模型大鼠胃腺体数目、腺体厚度、主细胞数目均有明显增加(P0.05～0.001);对HP模型大鼠胃组织炎症指标有显著降低作用(P0.001)。结论:胃乐煎对HP模型大鼠胃组织有明显的改善作用。

Effect of Weilejian on Pathology in Gastric of Rats with Helicobacter Pylori Associated Chronic Atrophic Gastritis

Objective: To observe the effect of Weilejian on pathology in gastric of rats with Helicobacter pylori(Sydney Strain 1,ss1) associated chronic atrophic gastritis(CAG).Methods: HP associated chronic atrophic gastritis models were induced(Rats were treated with sodium deoxycholate,then fed-J yuansuan Bijia Pian for clear rat stomach bacteria,And cultured HP(ss1) were orally administered).HP associated CAG rats were randomly divided into the groups treated with Weilejian with different doses.Inflammatory reaction,the thickness and the number of gastric glands,the number of parietal cells and chief cells in rat gastric mucosa were observed.Results: Weilejian can significantly increase body weight(P<0.05~0.01),can significantly increase the number of gastric glands,the glands thickness,the number of primary cells(P<0.05~0.001) and significantly reduce the indicators of gastric inflammation(P<0.001) for HP associated CAG.Conclusion: Weilejian can significantly improve the rat gastric tissue for HP associated CAG.