健脾泻肺法治疗非糜烂性胃食管反流病的临床观察

目的:观察健脾泻肺法治疗非糜烂性胃食管反流病的临床疗效。方法:将NERD患者,辨证属中虚气逆证共120例随机分为治疗者(60例)和对照组(60例),对照组采用雷贝拉唑、莫沙比利治疗;治疗组在此基础上,加用健脾泻肺法中药汤剂,两组疗程均为8周。观察治疗前后临床症状积分变化,并随访半年。结果:治疗后,两组症状积分较治疗前均有显著下降(P0.01),临床总有效率分别为93.33%、91.67%,差异无统计学意义(P0.05),但停药半年后复发情况比较,治疗组复发率为7.55%,明显低于对照组41.51%(P0.01)。结论:健脾泻肺法治疗非糜烂性胃食管反流病疗效确切,与西药合用远期疗效更佳。

Clinical Observation on Method of Invigorating Spleen And Weakening Lung to Treat Non-Erosive Reflux Disease

Objective:To observe the clinical effect of non-erosive reflux disease(NERD)by using the invigorating spleen and weakening lung treatment of TCM.Methods:120 patients with NERD of syndrome of middle deficiency and Qi reversal were randomly divided into two groups:treatment group(60 cases)and control group(60 cases).Patients in control group would be treated by rabeprazole and mosapride;patients in treatment group would be treated by rabeprazole,mosapride and the invigorating spleen and weakening lung treatment of TCM.The treatment course was 8 weeks.Symptom scores of NERD were measured before and after treatments,and followed for half a year.Results:After treatment,compared with pretreatment,the symptom scores decreased significantly in both groups(P<0.01);the total clinical effective rate of the treatment group was 93.33%,not significantly different from that of the control group 91.67%(P >0.05),but after half a year,the recurrence rate of the treatment group was 7.55%,much lower than that of the control group 41.51%(P<0.01).Conclusion:The invigorating spleen and weakening lung treatment of TCM was effective on NERD,and the long term effect could be better if integrated with western medicine.