| 低氧大鼠肺、肠组织VIP、P物质及CCK的表达差异分析 |
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| 引用本文： | 李立华,刘晓燕,刘声,郭霞珍.低氧大鼠肺、肠组织VIP、P物质及CCK的表达差异分析[J].中华中医药学刊,2012(7):1516-1518. |
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| 作者姓名： | 李立华 刘晓燕 刘声 郭霞珍 |
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| 作者单位： | 北京中医药大学基础医学院;山西中医学院 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)资助项目(2009CB522706) |
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| 摘 要： | 目的:分析不同状态下肺与空肠、回肠、结肠组织上的VIP、P物质、CCK表达差异,探讨肺与大肠的表里关系及它们之间的基础物质。方法:20只SD雌性大鼠随机分为正常组,低氧组,每组10只。低氧组大鼠给予每天8h低氧刺激,7天后取材。用放射免疫的方法测定两组大鼠肺、空肠、回肠、结肠组织的VIP、CCK及P物质的含量。结果:正常组大鼠的肺VIP、P物质及CCK与空肠组织VIP、P物质及CCK相比有明显差异(P0.05),与回肠、结肠没有明显差异(P0.05);低氧组大鼠的肺VIP、P物质及CCK与空肠相比也具有明显差异(P0.05),与回肠、结肠组织相比没有明显差异(P0.05)。结论:正常组大鼠肺与回肠、结肠没有差异,低氧组大鼠肺与回肠、结肠也没有差异。肺与大肠具有相表里关系。VIP、P物质及CCK是肺肠之间功能联系的物质基础。
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| 关 键 词： | 肺 大肠 表里关系 物质基础 |
Analysis on the Contents of VIP,SP and CCK in Lung and Intestine in Rat Model of Low-O2 |
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| LI Li-hua,LIU Xiao-yan,LIU Sheng,GUO Xia-zhen.Analysis on the Contents of VIP,SP and CCK in Lung and Intestine in Rat Model of Low-O2[J].Chinese Archives of Traditional Chinese Medicine,2012(7):1516-1518. |
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| Authors: | LI Li-hua LIU Xiao-yan LIU Sheng GUO Xia-zhen |
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| Institution: | 1(1.Basic Medical College of Beijing University of Chinese Medicine,Beijing 100029,China; 2.Shanxi University of Traditional Chinese Medicine,Taiyuan 030024,China) |
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| Abstract: | Objective:To observe the contents of VIP,SP and CCK in lung and intestine in different states,analysis on the relationship and the base material between the lung and intestine was made.Methods:The rat model of low-O2 was established,8hs everyday,and then the rats were killed after 7 days.VIP,SP and CCK were measured with Radioimmunoassay.Result:There were no significant differences in the contents of VIP,SP and CCK in lung and intestine in different states.Conclusion:The lung and the large intestine are interior-exteriorly related.VIP,SP and CCK are the base material between the lung and intestine. |
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| Keywords: | lung large intestine interior-exteriorly related material basis |
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