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| O~6-METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY AND SENSITIVITY OF 20 CHINESE TUMOR CELL STRAINS TO 1-(4-AMINO-2-METHYL-5-PYRIMIDINYL) METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA | |
| 引用本文： | 章扬培,Jiro Fujimoto,Kanji Ishizaki,陈建敏,范国才,Mituo Ikenaga. O~6-METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY AND SENSITIVITY OF 20 CHINESE TUMOR CELL STRAINS TO 1-(4-AMINO-2-METHYL-5-PYRIMIDINYL) METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA[J]. 中国癌症研究, 1992, 0(4) |
| 作者姓名： | 章扬培 Jiro Fujimoto Kanji Ishizaki 陈建敏 范国才 Mituo Ikenaga |
| 作者单位： | Department of Biochemistry，Institute of Radiation Medicine，Academy of Military Medical Sciences，Beijing.，Radiation Biology Center，Kyoto University，Japan，Radiation Biology Center，Kyoto University，Japan，Department of Biochemistry，Institute of Radiation Medicine，Academy of Military Medical Sciences，Beijing.，Department of Biochemistry，Institute of Radiation Medicine，Academy of Military Medical Sciences，Beijing.，Radiation Biology Center，Kyoto University，Japan |
| 摘 要： | O6-methylguanine-DNA methyltransferase (MGMT) plays an important role in repairing alkylated DNA. MGMT activity as well as cellular sensitivity to 1- ( 4- amino- 2-methyl-5-pyrimidinyl) methyl-3- ( 2-chloroethyl)-3-nitrosourea (ACNU) of 20 Chinese tumor cell strains were assayed. A linear response between MGMT activity and ACNU sensitivity (D10) was observed. The lower the MGMT activity In the cells, the more the sensitivity to ACNU killing. It suggested that assay of MGMT activity in tumor biopsy could be used as a guide to predict the effectiveness of ACNU treatment in chemotherapy of human cancer. |
O~6-METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY AND SENSITIVITY OF 20 CHINESE TUMOR CELL STRAINS TO 1-(4-AMINO-2-METHYL-5-PYRIMIDINYL) METHYL-3- (2-CHLOROETHYL)-3-NITROSOUREA |
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| Zhang Yangpei Jiro Fujimoto Kanji IshizakiChen Jianmin Fan Guocai Mituo Ikenaga. O~6-METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY AND SENSITIVITY OF 20 CHINESE TUMOR CELL STRAINS TO 1-(4-AMINO-2-METHYL-5-PYRIMIDINYL) METHYL-3- (2-CHLOROETHYL)-3-NITROSOUREA[J]. Chinese Journal of Cancer Research, 1992, 0(4) | |
| Authors: | Zhang Yangpei Jiro Fujimoto Kanji IshizakiChen Jianmin Fan Guocai Mituo Ikenaga |
| Affiliation: | Zhang Yangpei Jiro Fujimoto Kanji IshizakiChen Jianmin Fan Guocai Mituo IkenagaDepartment of Biochemistry,Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing. Radiation Biology Center,Kyoto University,Japan |
| Abstract: | O6-methylguanine-DNA methyltransferase (MGMT) plays an important role in repairing alkylated DNA. MGMT activity as well as cellular sensitivity to 1- ( 4- amino- 2-methyl-5-pyrimidinyl) methyl-3- ( 2-chloroethyl)-3-nitrosourea (ACNU) of 20 Chinese tumor cell strains were assayed. A linear response between MGMT activity and ACNU sensitivity (D10) was observed. The lower the MGMT activity In the cells, the more the sensitivity to ACNU killing. It suggested that assay of MGMT activity in tumor biopsy could be used as a guide to predict the effectiveness of ACNU treatment in chemotherapy of human cancer. |
| Keywords: | Chinese tumor cell strains O6-methylguanine-DNA methyltransferase ACNU sensitivity. |
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