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| 高三尖杉酯碱多相脂质体注射液物理性质的研究 | |
| 引用本文： | 唐世军,苏德森,顾学裘. 高三尖杉酯碱多相脂质体注射液物理性质的研究[J]. 药学学报, 1986, 21(8): 618-622 |
| 作者姓名： | 唐世军 苏德森 顾学裘 |
| 作者单位： | 沈阳药学院，沈阳药学院，沈阳药学院 沈阳化工研究院生物工程室 |
| 摘 要： | 研究了高三尖杉酯碱多相脂质体(代号139-5号) 注射液的重要物理性质:相转化温度、流变学性质及pH值对其荷电性的影响。测得139-5号注射液相转化温度为76.5℃。此注射液常温下为塑流型流体,随着温度升高,溶液趋于牛顿型流体。电泳测定表明,体系的粒子淌度在一定范围内随介质pH值升高而增大。 |
| 关 键 词： | 多相脂质体 高三尖杉酯碱 |
| 收稿时间： | 1985-04-03 |
STUDIES ON THE PHYSICAL PROPERTIES OF THE INJECTION OF POLYPHASE LIPOSOME OF HOMOHARRINGTONINE |
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| TANG Shi-Jun,SU De-Sen and GU Xue-Qiu. STUDIES ON THE PHYSICAL PROPERTIES OF THE INJECTION OF POLYPHASE LIPOSOME OF HOMOHARRINGTONINE[J]. Acta pharmaceutica Sinica, 1986, 21(8): 618-622 | |
| Authors: | TANG Shi-Jun SU De-Sen GU Xue-Qiu |
| Abstract: | The important physical properties of the injection of polyphase liposome of homoharringtonine (HH), named 139 number 5, the phase transition temperature, the rheopogical properties and influence of pH on the electrical charges were studied. The injection appeared to be Bingham type fluid at room temperature and tended to become Newton type fluid with increase of temperature. The result measured by electrophoresis showed that the particle mobility of the system increase with the pH of the medium to a certain extent. |
| Keywords: | Polyphase liposome Homoharringtonine |
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