| OGG1 Ser326Cys多态性与结直肠癌发病风险的meta分析 |
| |
| 引用本文： | 高天翼,李瑞,许晔琼,聂珍琳,顾玲,陈丽萍,宋国齐,王书奎. OGG1 Ser326Cys多态性与结直肠癌发病风险的meta分析[J]. 医疗设备信息, 2012, 0(11): 21-25 |
| |
| 作者姓名： | 高天翼 李瑞 许晔琼 聂珍琳 顾玲 陈丽萍 宋国齐 王书奎 |
| |
| 作者单位： | 南京医科大学附属南京第一医院中心实验室,江苏南京210006 |
| |
| 基金项目： | 国家自然科学基金（81172141）. |
| |
| 摘 要： | 目的对OGG1 Ser326Cys多态性与结直肠癌的关系做出更为准确的结论。方法通过对12篇文章采用meta分析评估OGG1 Ser326Cys多态性与结直肠癌发病率的关系。用合并比值比（OR）描述显性模型（Cys／CysvsSer／Ser；Ser／CysVSSer／Ser），主导模型（SedCys＋Cys／CysvsSer／Ser），隐性模型（Cys／CysVSSer／Cys＋Ser／Ser）。结果Cys／CysVSSer／Ser（OR=1．19，95％可信区间（CI）：0．92～1．53）、Ser／CysV8Ser／Ser（OR=1．04，95％CI=0．95-1．13）、SedCys＋Cys／CysVSSer／Ser（OR=1．06，95％CI=0．98～1．16）和Cys／CysVSSer／Cys＋Ser／Ser（OR=1．11．95％CI=0．90-1．38）无明显联系，此外，在分层分析中，所有基因型未见明显发病风险差异。结论meta分析表明OGG1 Ser326Cys多态性与结直肠癌总发病率无联系。
|
| 关 键 词： | 结直肠癌 多态性 OCGI |
meta Analysis of Association Between OGGI Ser326Cys Polymorphism and Colorectal Cancer Risk |
| |
| GAO Tian-yi,LI Rui,XU Ye-qiong,NIE Zhen-lin,GU Ling,CHEN Li-ping,SONG Guo-qi,WANG Shu-kui. meta Analysis of Association Between OGGI Ser326Cys Polymorphism and Colorectal Cancer Risk[J]. Information of Medical Equipment, 2012, 0(11): 21-25 |
| |
| Authors: | GAO Tian-yi LI Rui XU Ye-qiong NIE Zhen-lin GU Ling CHEN Li-ping SONG Guo-qi WANG Shu-kui |
| |
| Affiliation: | (Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing Jiangsu 210006, China) |
| |
| Abstract: | Objective To conclude the association between OGG1 Ser326Cys polymorphism and colorectal cancer （CRC）. Methods This meta analysis enrolls 12 papers to estimate the risk of OGG1 Ser326Cys polymorphism associated with CRC morbidity. The pooled odds ratio （OR） is performed for dominant model （Cys/Cys vs Ser/Ser; Ser/Cys vs Ser/Ser）, leading model （Ser/Cys＋Cys/Cys vs Ser/Ser） and recessive model （Cys/Cys vs Ser/Cys＋Ser/Ser）. Results No significant associations are found among Cys/Cys vs Ser/Ser （OR=1.19, 95%confidence interval （CI）=0.92-1.53）, Ser/Cys vs Ser/Ser （OR=1.04, 95%CI=0.95-1.13）, Ser/Cys＋Cys/Cys vs Ser/Ser （OR=1.06, 95%CI=0.98-1.16） and Cys/Cys vs Set/ Cys＋Ser/Ser （OR=I. 11, 95%CI=0.90- 1.38）, moreover, in stratified analysis, no significant differences in risk are found in all genetic models. Conclusion meta analysis indicates that OGG1 Ser326Cys polymorphism do not associate with CRC morbidity. |
| |
| Keywords: | colorectal cancer polymorphism OGG 1 |
| 本文献已被 维普 等数据库收录！ |
|
