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| 原位法制备羟基磷灰石/聚乳酸纳米复合材料的体外生物学研究 | |
| 引用本文： | Zhang C,Feng Q,Zhang T,Chen J,Lu C,Wu H. 原位法制备羟基磷灰石/聚乳酸纳米复合材料的体外生物学研究[J]. 生物医学工程学杂志, 2012, 29(2): 307-310 |
| 作者姓名： | Zhang C Feng Q Zhang T Chen J Lu C Wu H |
| 作者单位： | 安徽中医学院药学院安徽省高校省级现代中药重点实验室;中国科学院固体物理研究所材料物理重点实验室 |
| 基金项目： | 安徽省自然科学基金资助项目(10040606Q36);安徽省教育厅青年教师基金资助项目(2008JQL1094) |
| 摘 要： | 通过羟基磷灰石/聚乳酸(HA/PLLA)纳米复合材料在模拟体液(SBF)中的浸泡实验评价该材料的生物学性能。测试发现HA/PLLA纳米复合材料在浸泡过程中SBF的pH值呈现下降趋势,HA的存在缓冲了PLLA的酸性;复合材料表面有类骨磷灰石层沉积,并有"蚕茧状"类骨磷灰石颗粒和夹有短棒状晶体的片状晶体簇生成;同时复合材料的降解导致表面形成大量蜂巢状多孔。因此原位法制备的HA/PLLA纳米复合材料具有较好的生物活性和可降解性。 |
| 关 键 词： | 羟基磷灰石/聚乳酸纳米复合材料 体外实验 模拟体液 类骨磷灰石 生物活性 可降解性 |
In vitro biologic evaluation on nano-hydroxyapatite/poly (L-lactic acid) biocomposites fabricated using in-situ growth method |
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| Zhang Caiyun,Feng Qianfeng,Zhang Tao,Chen Jin,Lu Chuanhua,Wu Hongfei. In vitro biologic evaluation on nano-hydroxyapatite/poly (L-lactic acid) biocomposites fabricated using in-situ growth method[J]. Journal of biomedical engineering, 2012, 29(2): 307-310 | |
| Authors: | Zhang Caiyun Feng Qianfeng Zhang Tao Chen Jin Lu Chuanhua Wu Hongfei |
| Affiliation: | Anhui Key Laboratory of Modernized Chinese Material, School of Pharmacy, Anhui Traditional Chinese Medical College, Hefei 230038, China. cyzhang@issp.ac.cn |
| Abstract: | The aim of this research was to estimate the bioactivity of nano-hydroxyapatite/poly (L-lactic acid) composites in simulated body fluid. In vitro test showed that the pH value of simulated body fluid (SBF) declined gradually and the existence of hydroxyapatite (HA) particles neutralized the acid degradation product of poly (L-lactic acid) (PLLA). Bone-like apatite deposited on the surface, and silkworm-like crystals and plate-like clusters appeared after soaking. At the same time, there were many honeycomb-like pores caused by nano-composite degraded. The results indicated that the hydroxyapatite/poly (L-lactic acid) nano-composites have good bioactivity and degradation characteristics. |
| Keywords: | Hydroxyapatite/poly(L-lactic acid) nano-composites In vitro test Simulated body fluid(SBF) Bone-like apatite Bioactivity Degradation characteristics |
| 本文献已被 CNKI PubMed 等数据库收录！ | |