类风湿关节炎患者外周血维生素D水平的调查分析

目的研究类风湿关节炎(RA)患者外周血25羟维生素D3[25-(OH)D3]水平与疾病的相关性。方法 ELISA法检测72例绝经后女性RA患者(RA组)和58例健康的绝经后女性志愿者(对照组)外周血25-(OH)D3的水平,并采用疾病活动性评分(DAS28)评估RA患者疾病活动性,比较两组间25-(OH)D3水平的差异及25-(OH)D3与RA活动性之间的关系。结果与对照组相比,RA患者外周血25-(OH)D3水平明显降低(P<0.05),且25-(OH)D3水平与DAS28呈负相关。结论维生素D在类风湿关节炎疾病诊治过程中,可能起到防治及病情评估的双重作用。

An investigation on vitamin D levels in peripheral blood in rheumatoid arthritis

Objective To study the association between vitamin D levels and RA.Methods Seventy-two postmenopausal female patients with RA(group RA) and fifty-eight healthy volunteers(group control) were included in this study.25-hydroxyvitamin D3(25-(OH)D3) levels were determined by ELISA method and disease activity of RA was assessed according to the Disease Activity Score in 28 joints(DAS28).The difference of 25-(OH)D3 levels between two groups and the relationship between 25-(OH)D3 levels and DAS28 were assessed.Results 25-(OH)D3 levels in peripheral blood in group RA were significantly lower than that in group control(P<0.05),and 25-(OH)D3 levels were negatively correlated with DAS28.Conclusion Vitamin D may have double actions of prevention,treatment and evaluation during the diagnosis and treatment process with RA disease.