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| 基质金属蛋白酶在骨髓间充质干细胞迁移和分化中的作用 | |
| 引用本文： | Li X,Song G. 基质金属蛋白酶在骨髓间充质干细胞迁移和分化中的作用[J]. 生物医学工程学杂志, 2012, 29(2): 387-91, 396 |
| 作者姓名： | Li X Song G |
| 作者单位： | 重庆大学生物工程学院 |
| 基金项目： | 重庆市自然科学基金资助项目(2009bb5040);国家自然科学基金资助项目(11032012);中央高校基本科研业务费资助项目(CD-JXS112300) |
| 摘 要： | 基质金属蛋白酶(MMPs)属于细胞内的蛋白水解酶家族,因其需要Ca2+、Zn2+等金属离子作为辅助因子而得名,可以调节细胞外基质的形成、重塑、降解等,具有重要的生物学功能,参与多种生理病理过程。骨髓间充质干细胞(BMSCs)具有高度自我更新能力和多向分化潜能,可感知损伤信号迁移到组织损伤部位,进行增殖并分化为损伤组织细胞,在损伤组织的修复和再生中起着重要作用。BMSCs的迁移和分化行为受到MMPs及其抑制剂的调节,本文就MMPs在BMSCs分化和迁移中的作用做简要综述。 |
| 关 键 词： | 基质金属蛋白酶 间充质干细胞 分化 迁移 |
Roles of matrix metalloproteinase in migration and differentiation of bone marrow-derived mesenchymal stem cells |
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| Li Xiaona,Song Guanbin. Roles of matrix metalloproteinase in migration and differentiation of bone marrow-derived mesenchymal stem cells[J]. Journal of biomedical engineering, 2012, 29(2): 387-91, 396 | |
| Authors: | Li Xiaona Song Guanbin |
| Affiliation: | College of Bioengineering, Chongqing University, Chongqing 400044, China. |
| Abstract: | Matrix metalloproteinases (MMPs) are endocellular proteolytic enzymes. They are so named because they need Ca2+, Zn2+ and other metal ions as their cofactors. MMPs play an important biological role in regulating the formation, remodeling and degradation of extracellular matrix and participate in various physiological and pathological processes of cells. Bone marrow-derived mesenchymal stem cells (BMSCs) are a kind of pluripotent stem cell which has the ability to self-renew and differentiate into functional cells. Meanwhile, they can respond to the damage signals and migrate to injured site for tissue repair and regeneration. MMPs and their inhibitors TIMPs affect the differentiation and migration of BMSCs. This article reviews the roles of MMPs in differentiation and migration of BMSCs. |
| Keywords: | Matrix metalloproteinases(MMPs) Mesenchymal stem cells Differentiation Migration |
| 本文献已被 CNKI PubMed 等数据库收录！ | |