Bcl-2蛋白家族及其诱导的神经元凋亡

癫发作可启动神经元凋亡通路,线粒体位于凋亡通路的核心位置。Bcl-2家族蛋白是其上游重要的调控因子,它们通过转录水平、磷酸化-去磷酸化修饰、二聚体形成或水解剪切等机制精确调控内、外源性凋亡途径,最终决定神经元的存亡。对Bcl-2家族蛋白成员以及调控机制的研究有助于寻找新的干预手段,减少癫所致的神经元损伤。

Bcl-2 Family Proteins and Neuron Apoptosis Induced by Seizures

Seizures trigger the apoptotic pathway of neurons.Cell demise is often brought about by the activation of caspases,of which mitochondrial dysfunction is the best characterized.As the Bcl-2 family members reside upstream of irreversible cellular damage and focus much of their efforts at the level of mitochondria,they play a pivotal role in deciding whether a cell will live or die.Therefore,a thorough understanding and documentation of the epilepsy activated signaling pathways will provide us with necessary information to improve upon current therapeutic strategy against epilepsy induced brain damage.