幽门螺杆菌感染与胃癌预后的相关性研究

目的：观察胃癌患者幽门螺杆菌（Hp）感染率，研究Hp感染与胃癌术后患者预后的相关性。方法选取2009年1月至2010年8月90例来本院就诊的胃癌患者，根据感染Hp与否分为感染组（57例）和非感染组（33例）。比较两组患者的一般资料及3年内生存情况，采用Cox比例风险模型分析胃癌患者预后的独立危险因素。结果感染组的平均生存期为（25.75±4.25）个月高于未感染组的（14.32±3.96）个月（t=12.601，P＜0.05）。不同Lauren分型、淋巴结转移、局部浸润深度、远处转移以及根治性切除方面Hp感染比例差异均具有统计学意义（P均＜0.05）。Cox比例风险模型结果显示，年龄、淋巴结转移及浸润深度为胃癌患者预后的独立影响因素。结论 Hp感染可能通过影响淋巴结转移及浸润深度间接影响胃癌患者的预后，但并非独立影响因素。

Study on the correaltion between the Helicobacter pylori infection and prognosis of gastric cancer

Objective To investigate the Helicobacter pylori （HP） infection on gastric cancer patients, and study on the correlation between the HP infection and the prognosis of gastric cancer. Methods Total of 90 cases with gastric cancer were selected from January 2009 to August 2010 in our hospital, and divided into infection group （57 cases） and non-infection group （33 cases）. Two groups were compared on general information and three years of survival. Cox proportional hazards model analysis were used to find out the independent prognostic factor on patients with gastric cancer. Results The average survival time of infected group was （25.75 ± 4.25） months, which was more than that in the non-infected group which was （14.32 ± 3.96） months （t=12.601, P〈0.05）. Hp infection was signiifcantly on different Lauren classiifcation, lymph node metastasis, local invasion, distant metastasis and radical resection aspect （P all〈0.05）. Cox proportional hazards model showed：age, lymph node metastasis and depth of invasion of gastric cancer were independent prognostic factors. Conclusions Hp infection probably affect the prognosis of patients with gastric cancer by affecting lymph node metastasis and depth of invasion indirectly, but not independent factor.