富血小板血浆治疗症状性宫颈内膜移位的研究

目的：评价自体富血小板血浆注射对症状性宫颈内膜移位的治疗疗效。方法收集128例诊断为Ⅲ度症状性宫颈内膜移位患者，随机分为自体富血小板血浆（PRP）注射组（实验组）和微波组（对照组），阴道镜评估宫颈糜烂区愈合情况，应用Kirby-Baue抑菌圈试验评价PRP的抗菌性能，采用LIVE/DEAD BacLight死活菌试剂盒检测生物膜中细菌活力。结果 PRP体外具备良好的抗菌性能，临床随访表明PRP组和微波组6周后总有效率为96.8%（60/62）和80.0%（48/60），差异具有统计学意义（χ2=9.206，P＜0.05），富血小板血浆组宫颈创面愈合速度（5.3＆#177;2.1周）较微波组（7.9＆#177;2.8周）显著加快（χ2=7.206，P＜0.01）；PRP组治疗相关的不良反应（阴道分泌物及出血等）显著低于微波组，提示PRP具有很好的耐受性和安全性。结论自体PRP对治疗症状性宫颈内膜移位具有良好的应用前景。

Study on treating symptomatic cervical ectopy with platelet-rich plasma

Objective To evaluate the therapeutic effects of autologous platelet-rich plasma （PRP） injections to treat symptomatic cervical ectopy. Methods Total of 124 women diagnosed withⅢ ＆#176; symptomatic cervical ectopy were randomized to PRP group （study group） and microwave group （control group）. The wound healing of cervical erosion region were observed by colposcopy, antibacterial susceptibility of PRP gel was determined by Kirby-Bauer disc-diffusion, bacterial viability in bioiflms was detected by the LIVE/DEAD BacLight viability kit. Results The PRP treatment had good antibacterial properties in vitro. Clinical follow-up indicated that the total efifciency rates were 96.8%（60/62） for the PRP group and 80.0%（48/60） for the microwave group （χ2=9.206,P＆lt;0.05）. The cervical wound-healing of patients in PRP group signiifcantly quickly （5.3 ＆#177; 2.1 weeks） than those in the microscopy group （7.9 ＆#177; 2.8 weeks） （χ2=7.206,P＆lt;0.01）. Patients in PRP group with less treatment-related adverse reaction （vaginal discharge and bleeding） than that in the microwave group; PRP showed excellent tolerability and safety. Conclusion Autologous PRP applications have good potential for the treatment of symptomatic cervical ectopy.