祛栓灵胶囊对急性血瘀模型兔和大鼠血液流变学的改善研究

目的观察祛栓灵胶囊对急性血瘀模型动物兔和大鼠的血液流变学的影响。方法动物ig祛栓灵胶囊7 d后,分别以iv 10%高分子右旋糖酐和sc肾上腺素加冰浴制备兔和大鼠急性血瘀模型,然后分别测定血液流变学指标的变化。结果兔连续ig祛栓灵胶囊37.5~150 mg/kg 7 d后,可降低高分子右旋糖酐血瘀模型兔的全血黏度、全血还原黏度和红细胞聚集指数。大鼠连续ig祛栓灵胶囊62.5~250 mg/kg 7 d后,同样可降低sc肾上腺素＋冷刺激所致急性血瘀模型大鼠的全血黏度、血浆黏度、红细胞压积和纤维蛋白原。结论祛栓灵胶囊对急性血瘀兔和大鼠的血液流变学指标具有一定的改善作用。

Improvement of Qushuanling Capsule on hemorheology in rabbits and rats with acute blood stasis

Abstract： Objective To observe the effects of＇Qushuanling Capsule on the hemorheology in rabbits and rats with acute blood stasis. Methods After the animals were ig given Qushuanling Capsule for 7 d, the models of acute blood stasis were established bY means of iv giving rabbits 10% high molecular dextran solution and sc giving rats adrenalin plus swim in ice-bath, respectively. The changes of hemorheology were then observed. Results After ig administration for 7 d, Qushuanling Capsule at 37.5-- 150 mg/kg could decrease the whole blood viscosity, whole blood reduced viscosity, and erythrocyte aggregation index in rabbits with acute blood stasis. Qushuanling Capsule at 62.5 -- 250 mg/kg could also decrease the whole blood viscosity, plasma viscosity, hematoerit and fibrinogen in rats with acute blood stasis. Conclusion Qushuanling Capsule could improve the indexes of hemorheology in rabbits and rats with acute blood stasis in some extent,